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Citation
Eeken, J.C.J., Sobels, F.H. (1990). The effect of multi-locus deletions in heterozygotes; a model study using Drosophila.  Mutat. Res. 245(4): 267--275.
FlyBase ID
FBrf0052621
Publication Type
Research paper
Abstract

In a model study using Drosophila, we examined the heterozygous effects of a number of well-defined X-chromosomal deletions (i.e., those differing in location, but of about the same length, and those differing in length but located in the same general region), using relative viability and/or fertility as indicators. Most of the deletions were originally isolated in radiation or chemical mutagenesis experiments and maintained since then in stocks using appropriate balancer chromosomes. The results show that (i) most of the deletions have pronounced deleterious effects in heterozygotes; (ii) the size of the deletion per se is not a critical factor in determining relative heterozygous viability, but its location is and (iii) it is possible to tentatively identify, with respect to the deletions, putative genes that affect viability in Drosophila.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mutat. Res.
    Title
    Mutation Research
    Publication Year
    1964-
    ISBN/ISSN
    0027-5107
    Data From Reference