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Citation
Koh, Y.H., Popova, E., Thomas, U., Griffith, L.C., Budnik, V. (1999). Regulation of DLG localization at synapses by CaMKII-dependent phosphorylation.  Cell 98(3): 353--363.
FlyBase ID
FBrf0111569
Publication Type
Research paper
Abstract

Discs large (DLG) mediates the clustering of synaptic molecules. Here we demonstrate that synaptic localization of DLG itself is regulated by CaMKII. We show that DLG and CaMKII colocalize at synapses and exist in the same protein complex. Constitutively activated CaMKII phenocopied structural abnormalities of dlg mutant synapses and dramatically increased extrajunctional DLG. Decreased CaMKII activity caused opposite alterations. In vitro, CaMKII phosphorylated a DLG fragment with a stoichiometry close to one. Moreover, expression of site-directed dlg mutants that blocked or mimicked phosphorylation had effects similar to those observed upon inhibiting or constitutively activating CaMKII. We propose that CaMKII-dependent DLG phosphorylation regulates the association of DLG with the synaptic complex during development and plasticity, thus providing a link between synaptic activity and structure.

PubMed ID
PubMed Central ID
PMC4656018 (PMC) (EuropePMC)
Related Publication(s)
Review

Paper alert.
Murthy, 1999, Curr. Opin. Neurobiol. 9(5): 506--507 [FBrf0112227]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference