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Citation
Leiserson, W.M., Harkins, E.W., Keshishian, H. (2000). Fray, a Drosophila serine/threonine kinase homologous to mammalian PASK, is required for axonal ensheathment.  Neuron 28(3): 793--806.
FlyBase ID
FBrf0132433
Publication Type
Research paper
Abstract

Fray is a serine/threonine kinase expressed by the peripheral glia of Drosophila, whose function is required for normal axonal ensheathment. Null fray mutants die early in larval development and have nerves with severe swelling and axonal defasciculation. The phenotype is associated with a failure of the ensheathing glia to correctly wrap peripheral axons. When the fray cDNA is expressed in the ensheathing glia of fray mutants, normal nerve morphology is restored. Fray belongs to a novel family of Ser/Thr kinases, the PF kinases, whose closest relatives are the PAK kinases. Rescue of the Drosophila mutant phenotype with PASK, the rat homolog of Fray, demonstrates a functional homology among these proteins and suggests that the Fray signaling pathway is widely conserved.

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Related Publication(s)
Note

A glial investment of axons defrayed.
Einheber and Salzer, 2000, Neuron 28(3): 627--628 [FBrf0134804]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference