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General Information
Symbol
Dmel\fray07551
Species
D. melanogaster
Name
FlyBase ID
FBal0009600
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
l(3)07551
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The P{PZ} insertion in the first intron of fray in the 5' UTR.

The P{PZ}fray07551 insertion maps within both fray and CG7694 (transcription units with non-overlapping ORFs which share untranslated sequences).

Insertion components
P{PZ}fray07551
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The segmental nerves exhibit a frayed nerve phenotype - localised bulging and swellings are seen i the nerve. Defects range from mild bulging to immense bulges that exceed 300μm in length and 50μm in diameter.

Homozygotes die during the second larval instar stage. Embryos derived from homozygous female germ line clones show poor cuticle development.

Germline clones produce eggs with poor cuticle development.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference

fray[+]/fray07551 is a suppressor of visible phenotype of Scer\GAL4hh.PU, WnkEY10165

Other
Phenotype Manifest In
Suppressor of
Statement
Reference

fray[+]/fray07551 is a suppressor of wing vein | ectopic phenotype of Scer\GAL4hh.PU, WnkEY10165

fray[+]/fray07551 is a suppressor of wing vein L4 phenotype of Scer\GAL4hh.PU, WnkEY10165

Additional Comments
Genetic Interactions
Statement
Reference

fray07551/+ partially suppresses the penetrance of the wing phenotypes (additional veins around vein 5 and delta phenotypes at vein 4) caused by expression of WnkEY10165 under the control of Scer\GAL4hh.PU.

The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is suppressed by fray07551.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

A. Spradling.

Comments
Comments

FlyBase curator comment: Lethality described may be due to disruption of fray or overlapping CG7694 - both disrupted by FBti0005585.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (14)