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General Information
Symbol
Dmel\frayr1
Species
D. melanogaster
Name
FlyBase ID
FBal0121763
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
    Nature of the Allele
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Axons and glia may be separated by a large amount of extracellular space in mutant third larval instar nerves, in contrast to wild type.

    The segmental nerves exhibit a frayed nerve phenotype - localised bulging and swellings are seen i the nerve. This phenotype is 100% penetrant and the defects range from mild bulging to immense bulges that exceed 300μm in length and 50μm in diameter. The number of these bulges range from 8 to 22 per animal. Defasciculated axons are seen within these bulges. There is no strict relation between the presence of a bulge and its location along the nerve. Bulges are found in every nerve and nearly every segment, though there a higher tendency for bulges to occur near the ventral ganglion. For the A8 nerve a second hot spot is found at the levels of segments A6 and A7. Ultrastructural analysis reveals extensive errors in the glial ensheathement of axons, defects that are observed in both the bulging and non-bulging regions of the nerve. The bulging and non-bulging areas exhibit disrupted glial ensheathement. Glial processes that begin to extend circumferentially around the axons fall short of fully wrapping them. The proportion of ensheathing glial processes tha fully encircle the axons in mutants averages only about half in non-bulging compared to 85% in wild-type, though the total length of glial processes in mutants does not differ significantly from wild-type. Other glial errors include sites in the nerve where from three to seven glial processes converge to within half a micron but nevertheless fail to join up with each other. In addition to the glial defects, however the bulging regions contain large electron transparent regions which are presumably filled with fluid. The axons are severely defasciculated. The axons appear normal in number though their average axon diameter is slightly reduced when compared to wild-type. Otherwise all of the cellular components of a normal nerve are present in the bulges. The total length of glial processes appear normal.

    External Data
    Interactions
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    Phenotypic Class
    Suppressed by
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference

    Nerve bulge phenotype is rescued by the addition of Rnor\PASKScer\UAS.cLa and animals survive until pupal stage instead of the third instar.

    Complementation and Rescue Data
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    Mutant
    Wild-type
    Stocks (0)
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    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
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    Name Synonyms
    Secondary FlyBase IDs
      References (3)