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Lloyd, T.E., Atkinson, R., Wu, M.N., Zhou, Y., Pennetta, G., Bellen, H.J. (2002). Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila.  Cell 108(2): 261--269.
FlyBase ID
FBrf0144753
Publication Type
Research paper
Abstract

Signaling through tyrosine kinase receptors (TKRs) is thought to be modulated by receptor-mediated endocytosis and degradation of the receptor in the lysosome. However, factors that regulate endosomal sorting of TKRs are largely unknown. Here, we demonstrate that Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) is one such factor. Electron microscopy studies of hrs mutant larvae reveal an impairment in endosome membrane invagination and formation of multivesicular bodies (MVBs). hrs mutant animals fail to degrade active epidermal growth factor (EGF) and Torso TKRs, leading to enhanced signaling and altered embryonic patterning. These data suggest that Hrs and MVB formation function to downregulate TKR signaling.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Aberrations (1)
    Alleles (5)
    Gene Groups (1)
    Genes (8)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (3)