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Citation
Lee, J.H., Lee, E., Park, J., Kim, E., Kim, J., Chung, J. (2003). In vivo p53 function is indispensable for DNA damage-induced apoptotic signaling in Drosophila.  FEBS Lett. 550(1-3): 5--10.
FlyBase ID
FBrf0162129
Publication Type
Research paper
Abstract

p53 is a representative tumor suppressor whose dysfunction is a major cause of human cancer syndrome. Here we isolated flies lacking Dmp53, which encodes the single Drosophila orthologue of mammalian p53 family. Dmp53 null mutants well developed into adults, only displaying mild defects in longevity and fertility. However, genomic stability and viability of Dmp53 mutants dramatically decreased upon ionizing irradiation. Moreover, mutating Dmp53 abolished irradiation-induced apoptosis and reaper induction. These results indicate that Dmp53 is a central component of DNA damage-dependent apoptotic signaling.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    FEBS Lett.
    Title
    FEBS Letters
    Publication Year
    1968-
    ISBN/ISSN
    0014-5793
    Data From Reference
    Alleles (6)
    Genes (7)
    Insertions (2)
    Experimental Tools (2)
    Transgenic Constructs (2)