Straub, T., Dahlsveen, I.K., Becker, P.B. (2005). Dosage compensation in flies: mechanism, models, mystery. FEBS Lett. 579(15): 3258--3263.
FlyBase ID
FBrf0187569
Publication Type
Review
Abstract
Dosage compensation involves fine-tuning of gene expression at the level of entire chromosomes. The principles that assure selective targeting of the male X chromosome in Drosophila and the mechanism by which transcription levels are adjusted in a twofold range are still mysterious. We discuss the prevalent models in the context of recent experimental observations.
