Open Close
Reference
Citation
Bonasio, R., Lecona, E., Reinberg, D. (2010). MBT domain proteins in development and disease.  Semin. Cell Dev. Biol. 21(2): 221--230.
FlyBase ID
FBrf0210116
Publication Type
Review
Abstract

The Malignant Brain Tumor (MBT) domain is a "chromatin reader", a protein module that binds to post-translational modifications on histone tails that are thought to affect a variety of chromatin processes, including transcription. More specifically, MBT domains recognize mono- and di-methylated lysines at a number of different positions on histone H3 and H4 tails. Three Drosophila proteins, SCM, L(3)MBT and SFMBT contain multiple adjacent MBT repeats and have critical roles in development, maintenance of cell identity, and tumor suppression. Although they function in different pathways, these proteins all localize to chromatin in vivo and repress transcription by a currently unknown molecular mechanism that requires the MBT domains. The human genome contains several homologues of these MBT proteins, some of which have been linked to important gene regulatory pathways, such as E2F/Rb- and Polycomb-mediated repression, and to the insurgence of certain neurological tumors. Here, we review the genetics, biochemistry, and cell biology of MBT proteins and their role in development and disease.

PubMed ID
PubMed Central ID
PMC3772645 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Semin. Cell Dev. Biol.
    Title
    Seminars in cell and developmental biology
    Publication Year
    1996-
    ISBN/ISSN
    1084-9521
    Data From Reference
    Genes (3)