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Citation
Zhou, B., Yun, E.Y., Ray, L., You, J., Ip, Y.T., Lin, X. (2014). Retromer promotes immune quiescence by suppressing spätzle-toll pathway in Drosophila.  J. Cell. Physiol. 229(4): 512--520.
FlyBase ID
FBrf0223679
Publication Type
Research paper
Abstract

The Toll and Toll-like receptor signaling pathways are evolutionarily conserved pathways that regulate innate immunity in insects and mammals. While efforts have been made to clarify the signal transduction events that occur during infection, much less is known about the components that maintain immune quiescence. Here we show that retromer, an intracellular protein complex known for regulating vesicle trafficking, functions in modulating the Toll pathway in Drosophila melanogaster. In mutant animals lacking retromer function, the Toll pathway but not JAK-STAT or IMD pathway is activated, triggering both cellular and humoral responses. Genetic epistasis and clonal analysis suggest that retromer regulates a component that acts upstream of Toll. Our data further show that in the mutant the Toll ligand Spätzle has a processing pattern similar to that of after infection. Together, the results suggest a novel function of retromer in regulating Toll pathway and innate immunity at a step that modulates ligand processing or activity.

PubMed ID
PubMed Central ID
PMC4346153 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Cell. Physiol.
    Title
    Journal of Cellular Physiology
    Publication Year
    1966-
    ISBN/ISSN
    0021-9541
    Data From Reference
    Genes (14)