Golovnin, A.K., Molodina, V.V., Georgiev, P.G., Melnikova, L.S. (2016). Zinc finger domain of Su(Hw) protein is required for the formation of functional Su(Hw)-dependent insulator complex. Dokl. Biochem. Biophys. 469(1): 247--252.
FlyBase ID
FBrf0234617
Publication Type
Research paper
Abstract
This study is devoted to clarifying the role of Mod(mdg4)-67.2 and Su(Hw) proteins in the interaction between Su(Hw)-dependent insulator complexes and identifying the specific domains of the Su(Hw) protein required for insulation or mutual neutralization of insulators. Using genetic techniques and experiments in yeast two-hybrid system, we have demonstrated that the zinc finger domain of the Su(Hw) protein is involved in forming a functional insulator complex and cannot be replaced with the DNA-binding domain of the GAL4 protein.
