Mehringer, J., Navarro, J.A., Touraud, D., Schneuwly, S., Kunz, W. (2022). Phosphorylated resveratrol as a protein aggregation suppressor in vitro and in vivo. RSC Chem Biol 3(2): 250--260.
FlyBase ID
FBrf0253113
Publication Type
Research paper
Abstract
The stability of proteins in solution poses a great challenge for both technical applications and molecular biology, including neurodegenerative diseases. In this work, a phosphorylated resveratrol material was examined for its anti-aggregation properties in vitro and in vivo. Here, an anti-fibrillation effect could be measured for amyloid beta and human insulin in vitro and general anti-aggregation properties for crude chicken egg white in solution. Using a drosophila fly model for the overexpression of amyloid beta protein, changes in physiological protein aggregation and improved locomotor abilities could be observed in the presence of dietary phosphorylated resveratrol.
