Kubitz, Z., Goedken, J., O'Neill, B., DeWaard, L., Kinzer, J., Knutson, J., Mize, A., Toering Peters, S. (2025). Seizure Susceptibility in Drosophila melanogaster is Reduced with CBD and Z. jujube treatment. MicroPubl Biol 2025(): .
FlyBase ID
FBrf0264232
Publication Type
Research paper
Abstract
Seizures have a bidirectional relationship to sleep deprivation; sleep loss increases seizure susceptibility and duration, while seizures disrupt sleep (Mituzaite et al., 2021; Konduru et al., 2021). This study tested whether two treatments, cannabidiol (CBD) and Zizyphus jujube extract, reduced seizure activity in Drosophila melanogaster . We hypothesized the treatments would decrease seizure duration and increase seizure latency in sleep-deprived bang-sensitive (sesB [9Ed-4]) and temperature-sensitive (sei [P]) mutants, respectively. Sleep-deprived sesB [9Ed-4] flies treated with Z. jujube showed reduced seizure duration and both treatments increased seizure latency in sleep-deprived sei [P] flies. This demonstrates CBD and Z. jujube have anti-convulsant activity in the Drosophila model.
