FB2026_03 , released September 17, 2026
Recombinant Construct: P{Medea.myd88-int}
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General Information
Symbol
P{Medea.myd88-int}
FlyBase ID
FBtp0023219
Feature type
transgenic_transposable_element
Component Allele(s)
Myd88bnk.int
Myd88RNAi.bcd
Size
Expression Data
Associated insertion(s)
1 available
Molecular map
Description and Uses
Construct components
Component allele Myd88RNAi.bcd
Transgenic product class
RNAi_reagent
(Chen et al., 2007)
Component
Use(s)
Regulatory region(s)
bcd
Encoded product / tool
Myd88
Description

The bcd promoter drives expression of a transcript encoding two copies of mir-6-1 modified to target the Myd88 5' untranslated region.

(Chen et al., 2007)
Component allele Myd88bnk.int
Transgenic product class
wild_type
(Chen et al., 2007)
Component
Use(s)
Regulatory region(s)
bnk
Encoded product / tool
Myd88
Description

A bnk promoter drives expression of the Myd88 open reading frame. Myd88miRNA.bcd is located in an intron of Myd88bnk.int in opposite orientation.

(Chen et al., 2007)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments

The P{Medea.myd88-int} construct acts as a maternal-effect selfish genetic element. It contains a maternal toxin (Myd88miRNA.bcd) which consists of a maternal germline-specific promoter that drives expression of a product that is toxic to the embryo, and it also contains a zygotic antidote (Myd88bnk.int) which consists of a zygotic promoter driving expression of the antidote to the toxic maternal product. In P{Medea.myd88-int}, Myd88miRNA.bcd is located in an intron of Myd88bnk.int in opposite orientation.

(Chen et al., 2007)
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Medeamyd88-int
(Chen et al., 2007)
P{Medea.myd88-int}
(FlyBase, 1996-)
Secondary FlyBase IDs
    References (3)