A multigenic construct that expresses a a truncated Hsap\MYB protein and a hairpin cluster, each downstream of their own inducible UAS promoter. The truncated Hsap\MYB protein was found in a patient with adenoid cystic carcinoma - it lacks the C-terminal cytoplasmic domain required to regulate Hsap\MYB activity. The hairpin cluster targets orthologs of human ERCC2, FAT4, and FAT1/3 (Xpd, ft and kug, respectively), which harbored misssense mutations in the patient's tumor.
A multigenic construct that expresses a a truncated Hsap\MYB protein and a hairpin cluster, each downstream of their own inducible UAS promoter. The truncated Hsap\MYB protein was found in a patient with adenoid cystic carcinoma - it lacks the C-terminal cytoplasmic domain required to regulate Hsap\MYB activity. The hairpin cluster (version 12.2) targets orthologs of human ERCC2, FAT4, and FAT1/3 (Xpd, ft and kug, respectively), which harbored misssense mutations in the patient's tumor.
A multigenic construct that expresses a a truncated Hsap\MYB protein and a hairpin cluster, each downstream of their own inducible UAS promoter. The truncated Hsap\MYB protein was found in a patient with adenoid cystic carcinoma - it lacks the C-terminal cytoplasmic domain required to regulate Hsap\MYB activity. The hairpin cluster (version 12.2) targets orthologs of human ERCC2, FAT4, and FAT1/3 (Xpd, ft and kug, respectively), which harbored misssense mutations in the patient's tumor.
A multigenic construct that expresses a a truncated Hsap\MYB protein and a hairpin cluster, each downstream of their own inducible UAS promoter. The truncated Hsap\MYB protein was found in a patient with adenoid cystic carcinoma - it lacks the C-terminal cytoplasmic domain required to regulate Hsap\MYB activity. The hairpin cluster (version 12.2) targets orthologs of human ERCC2, FAT4, and FAT1/3 (Xpd, ft and kug, respectively), which harbored misssense mutations in the patient's tumor.