FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Recombinant Construct: P{UAS-Apc,Apc2,p53,Med,Pten,cic.sgRNA}
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General Information
Symbol
P{UAS-Apc,Apc2,p53,Med,Pten,cic.sgRNA}
FlyBase ID
FBtp0150464
Feature type
transgenic_transposable_element
Component Allele(s)
Apc2sgRNA.UAS
ApcsgRNA.UAS
cicsgRNA.UAS
MedsgRNA.UAS
p53sgRNA.UAS
PtensgRNA.UAS
Size
Expression Data
Associated insertion(s)
1 available
Molecular map
Description and Uses
Construct components
Component allele PtensgRNA.UAS
Transgenic product class
sgRNA
(Zipper et al., 2022)
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Pten
Description

UAS regulates expression of a sequence containing sgRNAs targeting Apc, Apc2, p53, Med, Pten and cic, which are the orthologs of the most frequently mutated tumor suppressors in colorectal cancer patients. Each sgRNA is flanked by tRNA sequences. Note that a knockout of cic could not be verified.

(Zipper et al., 2022)
Component allele MedsgRNA.UAS
Transgenic product class
sgRNA
(Zipper et al., 2022)
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Med
Description

UAS regulates expression of a sequence containing sgRNAs targeting Apc, Apc2, p53, Med, Pten and cic, which are the orthologs of the most frequently mutated tumor suppressors in colorectal cancer patients. Each sgRNA is flanked by tRNA sequences. Note that a knockout of cic could not be verified.

(Zipper et al., 2022)
Component allele cicsgRNA.UAS
Transgenic product class
sgRNA
(Zipper et al., 2022)
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
cic
Description

UAS regulates expression of a sequence containing sgRNAs targeting Apc, Apc2, p53, Med, Pten and cic, which are the orthologs of the most frequently mutated tumor suppressors in colorectal cancer patients. Each sgRNA is flanked by tRNA sequences. Note that a knockout of cic could not be verified.

(Zipper et al., 2022)
Component allele Apc2sgRNA.UAS
Transgenic product class
sgRNA
(Zipper et al., 2022)
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Apc2
Description

UAS regulates expression of a sequence containing sgRNAs targeting Apc, Apc2, p53, Med, Pten and cic, which are the orthologs of the most frequently mutated tumor suppressors in colorectal cancer patients. Each sgRNA is flanked by tRNA sequences. Note that a knockout of cic could not be verified.

(Zipper et al., 2022)
Component allele ApcsgRNA.UAS
Transgenic product class
sgRNA
(Zipper et al., 2022)
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Apc
Description

UAS regulates expression of a sequence containing sgRNAs targeting Apc, Apc2, p53, Med, Pten and cic, which are the orthologs of the most frequently mutated tumor suppressors in colorectal cancer patients. Each sgRNA is flanked by tRNA sequences. Note that a knockout of cic could not be verified.

(Zipper et al., 2022)
Component allele p53sgRNA.UAS
Transgenic product class
sgRNA
(Zipper et al., 2022)
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
p53
Description

UAS regulates expression of a sequence containing sgRNAs targeting Apc, Apc2, p53, Med, Pten and cic, which are the orthologs of the most frequently mutated tumor suppressors in colorectal cancer patients. Each sgRNA is flanked by tRNA sequences. Note that a knockout of cic could not be verified.

(Zipper et al., 2022)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments

UAS regulates expression of a sequence containing sgRNAs targeting Apc, Apc2, p53, Med, Pten and cic, which are the orthologs of the most frequently mutated tumor suppressors in colorectal cancer patients. Each sgRNA is flanked by tRNA sequences. Note that a knockout of cic could not be verified.

(Zipper et al., 2022)
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
P{UAS-Apc,Apc2,p53,Med,Pten,cic.sgRNA}
(FlyBase, 1996-)
apc1,apc2,cic,Med,p53,PtensgRNAs
(Zipper et al., 2022)
apc1,apc2,p53,Med,PtensgRNAs
(Zipper et al., 2022)
Secondary FlyBase IDs
    References (4)