FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Recombinant Construct: M{3xHisGU.H3K18Q.H4K8Q}
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General Information
Symbol
M{3xHisGU.H3K18Q.H4K8Q}
FlyBase ID
FBtp0170352
Feature type
transgenic_transposable_element
Component Allele(s)
His1HisGU.wt
His2AHisGU.wt
His2BHisGU.wt
His3HisGU.K18Q
His4HisGU.K8Q
Size
Expression Data
Associated insertion(s)
2 available
Molecular map
Description and Uses
Description

Three copies of the histone gene repeat unit (each repeat contains one copy of each of His1, His2A, His2B, His3 and His4). Each copy of the His3 gene has been mutated to contain the amino acid replacement K18Q and each copy of the His4 gene has been mutated to contain the amino acid replacement K8Q.

(Willnow and Teleman, 2024)
Construct components
Component allele His1HisGU.wt
Transgenic product class
wild_type
(Günesdogan et al., 2010)
Component
Use(s)
Regulatory region(s)
His1
Encoded product / tool
His1
Description

Wild-type His1 gene in the context of a histone gene repeat unit.

(Günesdogan et al., 2010)
Component allele His2AHisGU.wt
Transgenic product class
wild_type
(Günesdogan et al., 2010)
Component
Use(s)
Regulatory region(s)
His2A
Encoded product / tool
His2A
Description

Wild-type His2A gene in the context of a histone gene repeat unit.

(Günesdogan et al., 2010)
Component allele His2BHisGU.wt
Transgenic product class
wild_type
(Günesdogan et al., 2010)
Component
Use(s)
Regulatory region(s)
His2B
Encoded product / tool
His2B
Description

Wild-type His2B gene in the context of a histone gene repeat unit.

(Günesdogan et al., 2010)
Component allele His3HisGU.K18Q
Transgenic product class
missense_variant
(Willnow and Teleman, 2024)
polypeptide_post_translational_processing_variant
(Willnow and Teleman, 2024)
Component
Use(s)
Regulatory region(s)
His3
Encoded product / tool
His3
Description

Mutated His3 gene in the context of a histone gene repeat unit; contains a K18Q amino acid replacement (mutation mimics the loss of positive charge caused by acetylation).

(Willnow and Teleman, 2024)
Component allele His4HisGU.K8Q
Transgenic product class
missense_variant
(Willnow and Teleman, 2024)
polypeptide_post_translational_processing_variant
(Willnow and Teleman, 2024)
Component
Use(s)
Regulatory region(s)
His4
Encoded product / tool
His4
Description

Mutated His4 gene in the context of a histone gene repeat unit; contains a K8Q amino acid replacement (mutation mimics the loss of positive charge caused by acetylation).

(Willnow and Teleman, 2024)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
3xHis-GU H3Q18, H4Q8
(Willnow and Teleman, 2024)
M{3xHisGU.H3K18Q.H4K8Q}
(FlyBase, 1996-)
Secondary FlyBase IDs
    References (3)