FB2025_01 , released February 20, 2025
Allele: Dmel\Dap160EP2543
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General Information
Symbol
Dmel\Dap160EP2543
Species
D. melanogaster
Name
FlyBase ID
FBal0131268
Feature type
allele
Associated gene
Dmel\Dap160
Associated Insertion(s)
P{EP}Dap160EP2543
Carried in Construct
Also Known As
EP(2)2543
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{EP}Dap160EP2543
Cytology
Description

P{EP} insertion in the 5' untranslated region, in the second exon.

(Kelly and Phillips, 2005)

P{EP} insertion in the 5' UTR.

(Koh et al., 2004)

P{EP} insertion in the 5' untranslated region, 451bp upstream of the start ATG codon in the second exon.

(Marie et al., 2004)
Allele components
Component
Use(s)
Inserted element
P{EP}
Regulatory region(s)
UAS
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  amyotrophic lateral sclerosis type 8
      modeled by Vap33P58S.UAS.Tag:FLAG
      (Sanhueza et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes are phenotypically wild-type.

      (Kelly and Phillips, 2005)

      Overexpression of Dap160EP2468 under the control of Scer\GAL4GMR.PF produces a phenotypically wild-type wing.

      (Robertson et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Dap160EP2543, Scer\GAL4GMR.PF is an enhancer of wing vein | ectopic phenotype of CblDv.UAS, Scer\GAL4GMR.PF

      (Robertson et al., 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      stnA6/Y ; Dap160EP2543/Df(2L)TW65 males are viable but are somewhat late to eclose and are extremely uncoordinated as adults, dying within 48 hours of eclosion.

      stnB15/Y ; Dap160EP2543/Df(2L)TW65 males show about 35% survival compared to control siblings. The surviving adults are sedentary, extremely uncoordinated and exhibit an extreme stress-sensitive phenotype. They die within 3 days of eclosion.

      (Kelly and Phillips, 2005)

      Co-expression of CblDv.Scer\UAS with Dap160EP2468, both under the control of Scer\GAL4GMR.PF results in an increase in ectopic wing veins compared to expression of CblDv.Scer\UAS alone.

      (Robertson et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Dap160EP2543
      dap160EP2543
      (Hendricks and Liebl, 2024)
      Name Synonyms
      Secondary FlyBase IDs
        References (9)