FB2025_01 , released February 20, 2025
Allele: Dmel\parkUAS.Tag:HA
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General Information
Symbol
Dmel\parkUAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0158829
Feature type
allele
Associated gene
Dmel\park
Associated Insertion(s)
Carried in Construct
P{UAS-park.HA}
Key Links
Transgenic product class
cDNA
(Pesah et al., 2004)
wild_type
(Pesah et al., 2004)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Pesah et al., 2004)
wild_type
(Pesah et al., 2004)
Mutagen
in vitro construct
(Pesah et al., 2004)
Progenitor genotype
Carried in construct
P{UAS-park.HA}
Cytology
Description

Expression of the epitope tag Tag:HA is fused to the coding sequence of park (from the SD01679 EST clone in which a NarI fragment that includes nucleotide 760 has been replaced by equivalent sequence from EST clone AT25577) is under the control of UASt sequences.

(Pesah et al., 2004)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
park
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease 6
      modeled by Pink1RNAi.UAS.cYa
      (Liu and Lu, 2010)
      modeled by Pink1B9
      (Liu and Lu, 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      mitochondrion & dorso-lateral dopaminergic neuron, with Scer\GAL4ple.PF

      (Yang et al., 2008)
      Detailed Description
      Statement
      Reference

      Mitochondrial aggregates form in the dorsolateral protocerebral posterior DA (dopaminergic) neuron cluster in animals expressing parkScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ple.PF.

      (Yang et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      parkUAS.Tag:HA/Scer\GAL4ple.PF is a suppressor of mitochondrion & dorso-lateral dopaminergic neuron phenotype of Pink1B9

      (Yang et al., 2008)
      NOT Suppressor of
      Statement
      Reference

      parkUAS.Tag:HA/Scer\GAL4ple.PF is a non-suppressor of mitochondrion phenotype of Scer\GAL4ple.PF, mAcon1UAS.cEa

      (Esposito et al., 2013)

      parkUAS.Tag:HA/Scer\GAL4ple.PF is a non-suppressor of mitochondrion phenotype of Scer\GAL4ple.PF, mAcon1S677A.UAS

      (Esposito et al., 2013)

      parkUAS.Tag:HA, Scer\GAL4ple.PF is a non-suppressor of mitochondrion & dorso-lateral dopaminergic neuron phenotype of Pink1UAS.cYa, Scer\GAL4ple.PF

      (Yang et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Drp1+t9.4 does not rescue the defects in mitochondrial morphology seen in dopaminergic neurons expressing either AconS677A.Scer\UAS or AconScer\UAS.cEa under the control of Scer\GAL4ple.PF.

      (Esposito et al., 2013)

      The mitochondrial aggregation phenotype seen in the dorsolateral protocerebral posterior DA (dopaminergic) neuron cluster in animals expressing Pink1Scer\UAS.cYa under the control of Scer\GAL4ple.PF is not suppressed by co-expression of parkScer\UAS.T:Ivir\HA1.

      The mitochondrial aggregation phenotype seen in the dorsolateral protocerebral posterior DA (dopaminergic) neuron cluster in Pink1B9 animals is suppressed by expression of parkScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ple.PF.

      (Yang et al., 2008)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      parkScer\UAS.T:Ivir\HA1
      parkUAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (4)