FlyBase Allele Report: Dmel\Arfip[EY11874]

General Information

Symbol

Dmel\Arfip^EY11874

Species

D. melanogaster

Name

FlyBase ID

FBal0162068

Feature type

allele

Associated gene

Dmel\Arfip

Associated Insertion(s)

P{EPgy2}Arfip^EY11874

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gene Disruption Project members, 2001-)

Progenitor genotype

Associated Insertion(s)

P{EPgy2}Arfip^EY11874

Cytology

Description

Insertion in the 5' untranslated region of the longest CG17184 transcript.

(Korolchuk et al., 2007)

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:11,235,168..11,235,168 [-]

(Chang et al., 2013, Cheli et al., 2010, Korolchuk et al., 2007, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^Toll-6-D42

(Chang et al., 2013)

fertile

(Gene Disruption Project members, 2001-)

viable

(Gene Disruption Project members, 2001-)

Phenotype Manifest In

NMJ bouton | increased number | third instar larval stage, with Scer\GAL4^Toll-6-D42

(Chang et al., 2013)

Detailed Description

Statement

Reference

Expression of Arfip^EY11874 under the control of Scer\GAL4^D42 results in an increase in the number of boutons at the neuromuscular junction in third-instar larvae.

(Chang et al., 2013)

Primary cultured haemocytes from homozygous larvae internalise maleylated bovine serum albumin (mBSA) normally.

(Korolchuk et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Arfip^EY11874 is an enhancer of abnormal neuroanatomy | third instar larval stage phenotype of DCTN1-p150^Δ.UAS, Scer\GAL4^Toll-6-D42

(Chang et al., 2013)

Phenotype Manifest In

Enhancer of

Statement

Reference

Arfip^EY11874 is an enhancer of type Ib terminal bouton | third instar larval stage phenotype of DCTN1-p150^Δ.UAS, Scer\GAL4^Toll-6-D42

(Chang et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Arfip^EY11874 enhances the reduction in the number of type 1b boutons at the neuromuscular junction seen in third-instar larvae expressing Gl^Δ.Scer\UAS under the control of Scer\GAL4^D42. The number of synaptic retractions is suppressed.

(Chang et al., 2013)

Expression of CG17184^EY11874 under the control of Scer\GAL4^GMR.PF has no effect on the reduced red eye pigment phenotype of blos1^ex2 flies.

(Cheli et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

20706

y¹ w^67c23; P{EPgy2}Arfip^EY11874

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Arfip^EY11874

CG17184^EY11874

arfip^P1

(Chang et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

Open Close