FlyBase Allele Report: Dmel\Dronc[RNAi.UAS.cLa]

General Information

Symbol

Dmel\Dronc^RNAi.UAS.cLa

Species

D. melanogaster

Name

FlyBase ID

FBal0244087

Feature type

allele

Associated gene

Dmel\Dronc

Associated Insertion(s)

Carried in Construct

P{UAS-Dronc.RNAi.L}

Also Known As

UAS-dronc-IR, UAS-Dronc-RNAi

Key Links

Transgenic product class

RNAi_reagent

(Leulier et al., 2006)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Leulier et al., 2006)

Mutagen

in vitro construct

(Leulier et al., 2006)

Progenitor genotype

Carried in construct

P{UAS-Dronc.RNAi.L}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat of a fragment of Dronc.

(Leulier et al., 2006)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Dronc

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates carcinoma

modeled by Egfr^UAS.cBa, Socs36E^GD8929

(Xu et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

interommatidial precursor cell | pharate adult stage P9 | increased number, with Scer\GAL4^GMR.PF

(Leulier et al., 2006)

salivary gland | pupal stage, with Scer\GAL4^34B

(Leulier et al., 2006)

Detailed Description

Statement

Reference

Animals expressing Nc^{dsRNA.Scer\UAS.cLa} under the control of Scer\GAL4^GMR.PF have an aberrant number of pupal retinal lattice cells (68 hours after puparium formation).

Expression of Nc^{dsRNA.Scer\UAS.cLa} in the salivary glands under the control of Scer\GAL4^34B delays salivary gland histolysis during pupal development.

(Leulier et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Scer\GAL4^GMR.PF/Dronc^RNAi.UAS.cLa is a non-enhancer of visible phenotype of Dcp-1^ΔN.GMR

(Leulier et al., 2006)

Scer\GAL4^GMR.PF/Dronc^RNAi.UAS.cLa is a non-enhancer of visible phenotype of Strica^GMR.PX

(Leulier et al., 2006)

Suppressor of

Statement

Reference

Dronc^RNAi.UAS.cLa, Scer\GAL4^dpp.blk1 is a suppressor | partially of visible phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

Decay^RNAi.UAS.cLa, Scer\GAL4^GMR.PF, Dronc^RNAi.UAS.cLa is a suppressor of visible phenotype of hid^GMR.PG

(Leulier et al., 2006)

Scer\GAL4^GMR.PF, Dronc^RNAi.UAS.cLa, Strica^RNAi.UAS.cLa is a suppressor of visible phenotype of hid^GMR.PG

(Leulier et al., 2006)

Dronc^RNAi.UAS.cLa, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Diap1^RNAi.UAS.cLa, Scer\GAL4^GMR.PF

(Leulier et al., 2006)

Scer\GAL4^GMR.PF/Dronc^RNAi.UAS.cLa is a suppressor of visible phenotype of hid^GMR.PG

(Leulier et al., 2006)

NOT Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/Dronc^RNAi.UAS.cLa is a non-suppressor of visible phenotype of Strica^GMR.PX

(Leulier et al., 2006)

Scer\GAL4^GMR.PF/Dronc^RNAi.UAS.cLa is a non-suppressor of visible phenotype of Dcp-1^ΔN.GMR

(Leulier et al., 2006)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Scer\GAL4^GMR.PF/Dronc^RNAi.UAS.cLa is a non-enhancer of eye phenotype of Dcp-1^ΔN.GMR

(Leulier et al., 2006)

Scer\GAL4^GMR.PF/Dronc^RNAi.UAS.cLa is a non-enhancer of eye phenotype of Strica^GMR.PX

(Leulier et al., 2006)

Suppressor of

Statement

Reference

Dronc^RNAi.UAS.cLa, Scer\GAL4^dpp.blk1 is a suppressor | partially of wing phenotype of HIV-1\Vpu^UAS.cLa, Scer\GAL4^dpp.blk1

(Marchal et al., 2012)

Dronc^RNAi.UAS.cLa, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Diap1^RNAi.UAS.cLa, Scer\GAL4^GMR.PF

(Leulier et al., 2006)

Dronc^RNAi.UAS.cLa, Scer\GAL4^GMR.PF is a suppressor of interommatidial bristle phenotype of Diap1^RNAi.UAS.cLa, Scer\GAL4^GMR.PF

(Leulier et al., 2006)

Scer\GAL4^GMR.PF/Dronc^RNAi.UAS.cLa is a suppressor of eye phenotype of hid^GMR.PG

(Leulier et al., 2006)

Decay^RNAi.UAS.cLa, Scer\GAL4^GMR.PF, Dronc^RNAi.UAS.cLa is a suppressor of eye phenotype of hid^GMR.PG

(Leulier et al., 2006)

Scer\GAL4^GMR.PF, Dronc^RNAi.UAS.cLa, Strica^RNAi.UAS.cLa is a suppressor of eye phenotype of hid^GMR.PG

(Leulier et al., 2006)

NOT Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/Dronc^RNAi.UAS.cLa is a non-suppressor of eye phenotype of Strica^GMR.PX

(Leulier et al., 2006)

Scer\GAL4^GMR.PF/Dronc^RNAi.UAS.cLa is a non-suppressor of eye phenotype of Dcp-1^ΔN.GMR

(Leulier et al., 2006)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The adult wing defects caused by expression of HIV-1\Vpu^Scer\UAS.cLa under the control of Scer\GAL4^dpp.blk1 are partially suppressed by co-expression of Nc^{dsRNA.Scer\UAS.cLa}.

(Marchal et al., 2012)

Complementation and Rescue Data

Rescues

Scer\GAL4^GMR.PF/Dronc^RNAi.UAS.cLa rescues Dronc^pro.UAS

(Leulier et al., 2006)

Comments

Expression of Nc^{dsRNA.Scer\UAS.cLa} in animals expressing Nc^pro.Scer\UAS under the control of Scer\GAL4^GMR.PF rescues the eye phenotype observed when Nc^pro.Scer\UAS is expressed alone.

(Leulier et al., 2006)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Dronc^RNAi.UAS.cLa

Dronc^{dsRNA.Scer\UAS.cLa}

Dronc^{dsRNA.UAS.cLa}

Nc^{dsRNA.Scer\UAS.cLa}

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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