FlyBase Allele Report: Dmel\Gcn5[HMS00941]

General Information

Symbol

Dmel\Gcn5^HMS00941

Species

D. melanogaster

Name

FlyBase ID

FBal0257611

Feature type

allele

Associated gene

Dmel\Gcn5

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00941}

Also Known As

Gcn5^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00941}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00941

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | larval stage, with Scer\GAL4^dome-PG14

(Tiwari et al., 2020)

decreased cell number | progressive, with Scer\GAL4^Ugt36A1.PU

(Gonçalves et al., 2018)

Phenotype Manifest In

adult heart, with Scer\GAL4^tin.PU

(Gonçalves et al., 2018)

adult pericardial cell | progressive, with Scer\GAL4^Ugt36A1.PU

(Gonçalves et al., 2018)

cortical zone of lymph gland primary lobe | larval stage, with Scer\GAL4^dome-PG14

(Tiwari et al., 2020)

Detailed Description

Statement

Reference

Expression of Gcn5^HMS00941 under the control of Scer\GAL4^dome-PG14 (in combination with tub-Gal80[ts]) leads to a decline in the cortical zone of lymph gland primary lobe of larvae.

(Tiwari et al., 2020)

Expressing Gcn5^HMS00941 under the control of Scer\GAL4^Ugt36A1.PU results in a progressive decrease in the number of adult pericardial nephrocytes. Expression under the control of Scer\GAL4^tin.PU induces cardiac defects: a significant increase in arrhythmia index, significant decreases in cardiac output and diastolic diameter, but no changes in heart period, systolic diameter and fractional shortening.

Larval garland nephrocytes expressing Gcn5^HMS00941 under the control of Scer\GAL4^pros.PMG do not show obvious slit diaphragm defects.

(Gonçalves et al., 2018)

Expression of Gcn5^HMS00941 under the control of Scer\GAL4^bbg-C96 does not result in any obvious wing phenotype.

(Ellis et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Gcn5^HMS00941, Scer\GAL4^Ugt36A1.PU has decreased cell number | progressive phenotype, enhanceable by hts^KK101849, Scer\GAL4^Ugt36A1.PU

(Gonçalves et al., 2018)

Suppressed by

Statement

Reference

Gcn5^HMS00941, Scer\GAL4^Ugt36A1.PU, hts^KK101849 has decreased cell number | progressive phenotype, suppressible | partially by Hsap\ADD3^UAS.Tag:V5/Hsap\ADD1^UAS.Tag:HA, Scer\GAL4^Ugt36A1.PU

(Gonçalves et al., 2018)

NOT suppressed by

Statement

Reference

Gcn5^HMS00941, Scer\GAL4^Ugt36A1.PU, hts^KK101849 has decreased cell number | progressive phenotype, non-suppressible by Hsap\ADD3^{E659Q.UAS.Tag:V5}/Hsap\ADD1^UAS.Tag:HA, Scer\GAL4^Ugt36A1.PU

(Gonçalves et al., 2018)

Enhancer of

Statement

Reference

Gcn5^HMS00941, Scer\GAL4^Ugt36A1.PU is an enhancer of decreased cell number | progressive phenotype of Scer\GAL4^Ugt36A1.PU, hts^KK101849

(Gonçalves et al., 2018)

Gcn5^HMS00941, Scer\GAL4^bbg-C96 is an enhancer of visible phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Ellis et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

Gcn5^HMS00941, Scer\GAL4^Ugt36A1.PU has adult pericardial cell | progressive phenotype, enhanceable by hts^KK101849, Scer\GAL4^Ugt36A1.PU

(Gonçalves et al., 2018)

Gcn5^HMS00941, Scer\GAL4^tin.PU has adult heart phenotype, enhanceable by hts^KK101849, Scer\GAL4^tin.PU

(Gonçalves et al., 2018)

Suppressed by

Statement

Reference

Gcn5^HMS00941, Scer\GAL4^Ugt36A1.PU, hts^KK101849 has adult pericardial cell | progressive phenotype, suppressible | partially by Hsap\ADD3^UAS.Tag:V5/Hsap\ADD1^UAS.Tag:HA, Scer\GAL4^Ugt36A1.PU

(Gonçalves et al., 2018)

NOT suppressed by

Statement

Reference

Gcn5^HMS00941, Scer\GAL4^Ugt36A1.PU, hts^KK101849 has adult pericardial cell | progressive phenotype, non-suppressible by Hsap\ADD3^{E659Q.UAS.Tag:V5}/Hsap\ADD1^UAS.Tag:HA, Scer\GAL4^Ugt36A1.PU

(Gonçalves et al., 2018)

Enhancer of

Statement

Reference

Gcn5^HMS00941, Scer\GAL4^Ugt36A1.PU is an enhancer of adult pericardial cell | progressive phenotype of Scer\GAL4^Ugt36A1.PU, hts^KK101849

(Gonçalves et al., 2018)

Gcn5^HMS00941, Scer\GAL4^pros.PMG is an enhancer of slit diaphragm | larval stage phenotype of Scer\GAL4^pros.PMG, hts^KK101849

(Gonçalves et al., 2018)

Gcn5^HMS00941, Scer\GAL4^pros.PMG is an enhancer of embryonic/larval garland cell | larval stage phenotype of Scer\GAL4^pros.PMG, hts^KK101849

(Gonçalves et al., 2018)

Gcn5^HMS00941, Scer\GAL4^bbg-C96 is an enhancer of wing phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Ellis et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Gcn5^HMS00941 enhances the wing nicking phenotype of flies expressing dom^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^bbg-C96.

(Ellis et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

33981