FB2025_01 , released February 20, 2025
Gene Group: HEAT SHOCK PROTEIN 70 CHAPERONES
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General Information
Name
HEAT SHOCK PROTEIN 70 CHAPERONES
Species
D. melanogaster
Symbol
HSP70
FlyBase ID
FBgg0000497
Date last reviewed
2024-07-02
Number of members
13
Description
Description
The Heat Shock Protein 70 (Hsp70) superfamily of chaperones assist in numerous folding processes and are upregulated by heat stress and toxic chemicals. Hsp70 chaperones share a highly conserved bipartite domain structure composed of an ATPase domain and a substrate-binding domain. (Adapted from PMID:17441502, FBrf0232269 and FBrf0174945).
Notes on Group

Kaneko (2022, FBrf0253513) has further classified D. mel Hsp70s into cytosolic A, cytosolic B, ER, and mitochondrial linages based on phylogenetic analysis.

Source Material
The HEAT SHOCK PROTEIN 70 CHAPERONES Gene Group has been compiled using the following publication(s): Kaneko, 2022, Ratheesh et al., 2012, Takahashi et al., 2010, and Nikolaidis and Nei, 2004 .
Key Gene Ontology (GO) terms
Molecular Function
ATP-dependent protein folding chaperone
Biological Process
response to heat
Cellular Component
Related Gene Groups
Parent group(s)
ATP-DEPENDENT PROTEIN FOLDING CHAPERONES
HEAT SHOCK PROTEINS
Members (13)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG7182
(FlyBase, 2017-)
Hsc70-1
Heat shock protein 70 cognate 1
Hsc70, Heat shock protein cognate 1, Hsc1
(Kaneko, 2022, Ratheesh et al., 2012)
Hsc70-2
Heat shock protein 70 cognate 2
Hsc70, hsc2, Hsc70.2, Heat shock protein cognate 2
(Kaneko, 2022, Ratheesh et al., 2012, Nikolaidis and Nei, 2004)
Hsc70-3
Heat shock protein 70 cognate 3
BiP, Hsc3, Hsc70, Grp78, Hsc-70-3
(Kaneko, 2022, Ratheesh et al., 2012, Nikolaidis and Nei, 2004)
Hsc70-4
Heat shock protein 70 cognate 4
Hsc4, Hsc70, Heat shock protein cognate 4, BAP74, Hsp70
(Kaneko, 2022, Ratheesh et al., 2012, Nikolaidis and Nei, 2004)
Hsc70-5
Heat shock protein 70 cognate 5
Hsc5, Hsc70, Heat shock protein cognate 5, l(2)k04907, Heat shock 70 kDa protein cognate 5
(Kaneko, 2022, Ratheesh et al., 2012, Nikolaidis and Nei, 2004)
Hsp68
Heat shock protein 68
68
(Kaneko, 2022, Ratheesh et al., 2012)
Hsp70Aa
Heat shock protein 70 Aa
hsp70, Hsp70A, hsp-70, heat-shock protein 70, hsp70 87A
(Kaneko, 2022, Nikolaidis and Nei, 2004)
Hsp70Ab
Heat shock protein 70 Ab
hsp70, Hsp70A, hsp-70, heat-shock protein 70
(Kaneko, 2022, Ratheesh et al., 2012, Nikolaidis and Nei, 2004)
Hsp70Ba
Heat shock protein 70 Ba
hsp70, Hsp70B, heat-shock protein 70, hsp-70, hsp70 87C
(Kaneko, 2022, Ratheesh et al., 2012, Takahashi et al., 2010, Nikolaidis and Nei, 2004)
Hsp70Bb
Heat shock protein 70 Bb
hsp70, Hsp70B, Hsp70Bc, hsp-70, heat-shock protein 70
(Kaneko, 2022, Ratheesh et al., 2012, Takahashi et al., 2010, Nikolaidis and Nei, 2004)
Hsp70Bbb
Heat shock protein 70 Bbb
Hsp70, hsp70B, heat-shock protein 70
(Kaneko, 2022, Ratheesh et al., 2012, Takahashi et al., 2010)
Hsp70Bc
Heat shock protein 70 Bc
hsp70, Hsp70B, heat-shock protein 70, hsp-70
(Kaneko, 2022, Takahashi et al., 2010, Nikolaidis and Nei, 2004)
External Data
Equivalent Group(s)
Other resource(s)

[Heat shock protein information resource:Hsp70 ](http://pdslab.biochem.iisc.ernet.in/hspir/hsp70.php)

Synonyms and Secondary IDs
Synonym(s)
HSP70
HEAT SHOCK PROTEIN 70 CHAPERONES
Heat shock proteins 70kDa
Secondary FlyBase ID(s)
References (6)