Reference Report

Reference
Citation	Jones, B.W., Fetter, R.D., Tear, G., Goodman, C.S. (1995). glial cells missing: a genetic switch that controls glial versus neuronal fate. Cell 82(6): 1013--1023. (Export to RIS)
FlyBase ID	FBrf0084071
Publication Type	Research paper
PubMed ID	7553843
PubMed Abstract	The glial cells missing (gcm) gene in Drosophila encodes a novel nuclear protein that is transiently expressed early in the development of nearly all glia. In loss-of-function gcm mutant alleles, nearly all glia fail to differentiate, and, where we can follow them in the PNS, are transformed into neurons. In gain-if-function gcm conditions using transgenic constructs that drive ectopic gcm expression, many presumptive neurons are transformed into glia. Thus, gcm appears to function as a binary genetic switch for glia versus neurons. In the presence of gcm protein, presumptive neurons become glia, while in its absence, presumptive glia become neurons.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (1)
	Df(2L)200
Alleles (18)
	Ecol\lacZ^AA142 Ecol\lacZ^gcm-rA87 gcm¹³⁰⁸ gcm^N7-4 gcm^rA87 gcm^Scer\UAS.cJa gcm^ΔP1 gcm^ΔP2 gcm^ΔP3 gcm^ΔP4 gcm^ΔP5 gcm^ΔP6 gcm^ΔP7 gcm^ΔP8 gcm^ΔP9 gcm^ΔP10 Scer\GAL4^elav-C155 w^+mC
Constructs (2)
	P{UAS-gcm.J} pP{UAS-gcm.J}
Genes (5)
	Ecol\lacZ gcm repo Scer\GAL4 w
Insertions (3)
	P{GawB}elav^C155 P{lwB}AA142 P{PZ}gcm^rA87