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Reference
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| Citation |
Lebestky, T., Chang, T., Hartenstein, V., Banerjee, U. (2000). Specification of Drosophila hematopoietic lineage by conserved transcription factors. Science 288(5463): 146--149. |
| FlyBase ID |
FBrf0127186 |
| Type of publication |
Research paper |
| Offprint Available |
Yes |
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External Crossreferences
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| PubMed ID |
10753120 |
| PubMed Abstract |
Two major classes of cells observed within the Drosophila hematopoietic repertoire are plasmatocytes/macrophages and crystal
cells. The transcription factor Lz (Lozenge), which resembles human AML1 (acute myeloid leukemia- 1) protein, is necessary
for the development of crystal cells during embryonic and larval hematopoiesis. Another transcription factor, Gcm (glial cells
missing), has previously been shown to be required for plasmatocyte development. Misexpression of Gcm causes crystal cells
to be transformed into plasmatocytes. The Drosophila GATA protein Srp (Serpent) is required for both Lz and Gcm expression
and is necessary for the development of both classes of hemocytes, whereas Lz and Gcm are required in a lineage-specific manner.
Given the similarities of Srp and Lz to mammalian GATA and AML1 proteins, observations in Drosophila are likely to have broad
implications for understanding mammalian hematopoiesis and leukemias.
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| Biosis |
2000.322114 |
| Zoological record |
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Associated Information
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| Comments |
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| Text of personal communication |
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| Associated files |
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Related Publications
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| Supplementary material |
Specification of Drosophila hematopoietic lineage by conserved transcription factors. [FBrf0129252]
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Also Published As
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Other Reference Information
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| Secondary IDs |
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| Language of publication |
English |
| Additional language(s) of abstract |
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| ISBN |
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| Place of publication |
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Published In
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| Abbreviation |
Science |
| Title |
Science |
| Authors |
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| Volume range |
1- |
| Year range |
1895- |
| Page range |
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| Publisher |
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| Place of publication |
Washington, DC |
| Language of publication |
English |
| ISBN/ISSN |
0036-8075 |
| CODEN |
SCIEAS |
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Data from Reference
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| Alleles (7)
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| Constructs (1)
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| Genes (7)
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| Insertions (2)
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