Reference Report

Reference
Citation	Menon, K.P., Sanyal, S., Habara, Y., Sanchez, R., Wharton, R.P., Ramaswami, M., Zinn, K. (2004). The Translational Repressor Pumilio Regulates Presynaptic Morphology and Controls Postsynaptic Accumulation of Translation Factor eIF-4E. Neuron 44(4): 663--676. (Export to RIS)
FlyBase ID	FBrf0180581
Publication Type	Research paper
PubMed ID	15541314
PubMed Abstract	Translational repression by Drosophila Pumilio (Pum) protein controls posterior patterning during embryonic development. Here, we show that Pum is an important mediator of synaptic growth and plasticity at the neuromuscular junction (NMJ). Pum is localized to the postsynaptic side of the NMJ in third instar larvae and is also expressed in larval neurons. Neuronal Pum regulates synaptic growth. In its absence, NMJ boutons are larger and fewer in number, while Pum overexpression increases bouton number and decreases bouton size. Postsynaptic Pum negatively regulates expression of the translation factor eIF-4E at the NMJ, and Pum binds selectively to the 3'UTR of eIF-4E mRNA. The GluRIIa glutamate receptor is upregulated in pum mutants. These results, together with genetic epistasis studies, suggest that postsynaptic Pum modulates synaptic function via direct control of eIF-4E expression.
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Neuron
Title	Neuron
Publication Year	1988-
ISBN/ISSN	0896-6273
Data from Reference
Aberrations (1)
	Df(3R)BSC24
Alleles (8)
	eIF-4E^Scer\UAS.cRa pum⁷ pum⁹ pum^Msc pum^RBD.Scer\UAS pum^Scer\UAS.fl Scer\GAL4^elav-C155 Scer\GAL4^{Mhc.Switch.PO}
Constructs (4)
	P{Mhc-Switch.O} P{UAS-eIF-4E.R} P{UAS-pum.fl} P{UAS-pum.RBD}
Genes (4)
	eIF-4E GluRIIA pum Scer\GAL4
Insertions (1)
	P{GawB}elav^C155
Natural transposons (1)
	P-element