FlyBase Aberration Report: Dmel\In(3LR)TM6B

General Information

Symbol

In(3LR)TM6B

Species

D. melanogaster

Name

FlyBase ID

FBab0005465

Feature type

chromosomal_inversion

Computed Cytological Breakpoints (relative to progenitor)

Sequenced Breakpoints (relative to progenitor)

3L:18,693,657..18,693,657 (In(3LR)TM6B:bk1)

(Miller et al., 2016)

3R:22,393,827..22,393,827 (In(3LR)TM6B:bk2)

(Miller et al., 2016)

3L:3,173,046..3,173,046 (In(3LR)TM6B:bk3)

(Miller et al., 2016)

3L:16,308,841..16,308,841 (In(3LR)TM6B:bk4)

(Miller et al., 2016)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

3Lt - 61A1 | 87B2 - 86C8 | 84F2 - 86C7 | 84B2 - 84F2 | 84B2 - 75C | 94A - 100F2 | 92D1 - 87B4 | 61A2 - 63B8 | 72E1 - 63B11 | 72E2 - 75C | 94A - 92E1 | 100F3 - 3Rt

Progenitor

(Craymer, 1984)

(Craymer, 1984)

(Craymer, 1984)

Mutagen

Class of aberration (relative to wild type)

chromosomal_inversion

Class of aberration (relative to progenitor)

Cytological Breakpoints (relative to progenitor)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

Genetic mapping information

Comments

One of two 3L breakpoints of In(3L)P.

(Miller et al., 2016)

The 3L breakpoint of In(3LR)M6.

(Miller et al., 2016)

The 3R breakpoint of In(3LR)M6.

(Miller et al., 2016)

Comments on Cytology

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Glut4EF

(Yazdani et al., 2008)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (0)

If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
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Related Comments

Phenotypic Data

In combination with other aberrations

NOT in combination with other aberrations

Stocks (0)

Notes on Origin

Discoverer

Craymer, 1982.

(Craymer, 1984)

TM6B was generated by recombining TM6 with a chromosome carrying In(3LR)HR33 (61A1-2;87B) and inside it, In(3R)Hu (breaks in 84B1;84F2;86C7-8 resulting in the following order left to right inside In(3LR)HR33: 61A1-86C8|84F2-86C7|84B2-84F2|84B2-61A2). The recombination resulted in the replacement of the left end of In(3LR)P88 with the left end of In(3LR)HR33 including In(3R)Hu. The right breakpoint of In(3LR)P88 (order 89C4|61A2) was replaced with the right breakpoint of In(3LR)HR33 (order 87B4|61A2) by double crossover to compensate for the deficiency created by introducing the left end of In(3LR)HR33. Early TM6B versions usually included D³ or Tb¹, also introduced by double crossover (FBrf0063387, FBrf0232806). In most stocks today, TM6B is marked with Tb¹ or is derived from a TM6B chromosome that was previously marked with Tb¹, but in which the Tb¹ marker has since reverted or become suppressed.

(Parks and Cook, 2026.8.6)

Balancer / Genotype Variants of the Aberration

TM6B

(Miller et al., 2020, Miller et al., 2019, Miller et al., 2016, Lattao et al., 2011, Weiler, 2007, FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 1998.5.16, Lindsley and Zimm, 1992)

TM6B-22UZ

(FlyBase Curators, 2006-)

TM6B,abdA-LacZ

(FlyBase Curators, 2006-)

TM6B.Scr-lacZ

(FlyBase Curators, 2006-)

TM6b^T8LZ

(FlyBase Curators, 2006-)

TM6B-Bri¹

TM6B-BT

(FlyBase Curators, 2006-)

TM6B-D

(FlyBase Curators, 2006-)

TM6B-Dl

(FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)

TM6B-Dup99B^TM6B

(FlyBase Curators, 2006-)

TM6B-gT

(FlyBase Curators, 2006-)

TM6B-P

(FlyBase Curators, 2006-)

TM6B-P{Crew}

(FlyBase Curators, 2006-)

TM6B-P{Dfd-EYFP}3

(FlyBase Curators, 2006-, Le et al., 2006)

TM6B-P{Dfd-GMR-nvYFP}4

(Beitel, 2007.4.20)

TM6B-P{HZ2.7}3

(FlyBase Curators, 2006-)

TM6B-P{nanos-FLPD5.K}3

(Hibbard, 2024.7.29)

TM6B-P{Tub-AcrIIA4.RFP+}3r

(Han, 2025-)

TM6B-P{Tub-AcrIIA4.w+}3w

(Han, 2025-)

TM6B-P{UAS-rpr.C}3,Tb¹

(Sekelsky, 2013.10.1)

TM6B-P{Ubi-p63E-Grip84.C}

(Bartoszewski et al., 2022)

TM6B-p^Xp

(FlyBase Curators, 2006-)

TM6B-rT

(FlyBase Curators, 2006-)

TM6B-rTc

(FlyBase Curators, 2006-)

TM6B-ry^CBTb¹

(FlyBase Curators, 2006-)

TM6B-ry^CBTb⁺

(FlyBase Curators, 2006-)

TM6B-Sb¹

(FlyBase Curators, 2006-)

TM6B-SX4

(Kim et al., 2023)

TM6B-Tb⁺

(FlyBase Curators, 2006-)

TM6B-Tb⁺ca¹

(FlyBase Curators, 2006-)

TM6B-Tb⁺e⁺

(FlyBase Curators, 2006-)

TM6B-Tb-BlastR-5FCS

(Matinyan et al., 2021)

TM6B-Tb-G418R-5FCS

(Matinyan et al., 2021)

TM6B-Tb-P{UAS.RMCE.w⁺}1A

(Matinyan et al., 2021)

TM6B-Tb-P{UAS.RMCE.w⁺}5A

(Matinyan et al., 2021)

TM6B-Tb-P{UAS-Delta.Bgl.Myc}3

(Parks and Muskavitch, 2009.3.2)

TM6B-Tc

(FlyBase Curators, 2006-)

TM6B-TD

(FlyBase Curators, 2006-)

TM6B-tub-Gal80

(FlyBase Curators, 2006-)

TM6B-UZ

(FlyBase Curators, 2006-)

TM6B-vDAa

(FlyBase Curators, 2006-)

TM6B-vGa

(FlyBase Curators, 2006-)

TM6B-vGb

(FlyBase Curators, 2006-)

TM6B-vHa

(FlyBase Curators, 2006-)

TM6B-y⁺

(FlyBase Curators, 2006-)

Separable Components

Other Comments

An unknown female sterile mutation was present near the distal end of In(3R)C in the progenitor TM6 chromosome; consequently, deficiencies removing a region within 92F cannot be maintained over TM3.

(Parks and Cook, 2026.8.6)

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

In(3LR)TM6B

TM6B

(Parks and Cook, 2026.8.6, Michel et al., 2004)

Name Synonyms

Third Multiple Six, B structure

(Craymer, 1984)

Secondary FlyBase IDs

References (59)

Report Sections

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