FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Aberration: Dmel\Dp(1;f)10B
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General Information
Symbol
Dp(1;f)10B
Species
D. melanogaster
Name
FlyBase ID
FBab0024543
Feature type
free_duplication
Also Known As
10B
Computed Breakpoints include
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Dp(1;f)γ238
(Cook et al., 1997, Donaldson and Karpen, 1997, Murphy and Karpen, 1995)
Mutagen
gamma ray
(Cook et al., 1997, Donaldson and Karpen, 1997, Murphy and Karpen, 1995)
Class of aberration (relative to wild type)
free_duplication
Class of aberration (relative to progenitor)
chromosomal_deletion
(Murphy and Karpen, 1995)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data
Genetic mapping information
Comments
Comments on Cytology

"Terminal" deletion.

(Donaldson and Karpen, 1997)

Used in experiments that showed that efficient achiasmate homolog disjunction in female meiosis I requires 1000kb of overlap in the centric heterochromatin and is not affected by homologous euchromatin or overall size differences. Disjunction efficiency decreases linearly as heterochromatic overlap is reduced from 1000 to 430kb. Rescue experiments with nod transgenes showed that heterochromatin does not act solely to promote chromosome movement or spindle attachment. Centric heterochromatin seems to contain multiple pairing elements that act additively to initiate or maintain the proper alignment of achiasmate chromosomes in meiosis I.

(Karpen et al., 1996)
Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
y
(Murphy and Karpen, 1995)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
ry
(Murphy and Karpen, 1995)
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
    In these cases, there will be no "Export to Hitlist" button to the left.
    Phenotypic Data
    In combination with other aberrations

    Dp(1;f)γ878/Dp(1;f)10B heterozygotes increases y+ expression, to 35% of full Dp(1;f)γ158 trans-suppression. y+ expression is quantitated in triple row bristles.

    (Donaldson and Karpen, 1997)
    NOT in combination with other aberrations

    Transmission rate through females to progeny is 50% in the first 5 days of egg lay. nod, nod, ncd and Klp3A mutations and mei-S332 ord double mutants cause a mild reduction in transmission. One or two extra copies of nod provided by P{flag-nodhsp} partially rescues transmission.

    (Cook et al., 1997)
    Stocks (0)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    Acentric mini-chromosomes are lost at a moderate but elevated rate during male germline mitotic divisions and in female mitosis, but appear to be transmitted efficiently through pre-blastoderm mitoses and male meiosis. mit(1)15 can localise to the mini-chromosome.

    (Williams et al., 1998)

    Minichromosome is 720bp in length.

    (Cook et al., 1997)

    Contains 400kb of centric heterochromatin in inverted orientation.

    (Donaldson and Karpen, 1997)

    Monosome transmission behaviour from both male and female parents is stable demonstrating normal transmission and normal centromere function.

    (Murphy and Karpen, 1995)
    Synonyms and Secondary IDs (4)
    Reported As
    Symbol Synonym
    10B
    (Blower and Karpen, 2001, Williams et al., 1998, Cook et al., 1997, Donaldson and Karpen, 1997, Sun et al., 1997)
    Dp(1;f)10B
    Dp(1;f)γ10B
    Dp10B
    (Sullivan and Karpen, 2001)
    Name Synonyms
    Secondary FlyBase IDs
    • FBab0026886
    References (8)