FlyBase Allele Report: Dmel\βTub60D[4]

General Information

Symbol

Dmel\βTub60D⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0000023

Feature type

allele

Associated gene

Dmel\βTub60D

Associated Insertion(s)

Carried in Construct

Also Known As

B3t⁴

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Kimble et al., 1990)

Mutagen

ethyl methanesulfonate

(Dettman et al., 1996, Kimble et al., 1990)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

flightless

(Kimble et al., 1990)

lethal | recessive

(Dettman et al., 1996)

male sterile | recessive

(Kimble et al., 1990)

partially lethal - majority die | recessive

(Dettman et al., 1996)

partially lethal - majority live (with βTub60D¹)

(Hoyle et al., 2000)

sterile (with βTub60D¹)

(Dettman et al., 1996)

sterile (with βTub60D¹⁰)

(Dettman et al., 1996)

sterile (with βTub60D^P126)

(Dettman et al., 1996)

sterile (with βTub60D^sk)

(Dettman et al., 1996)

viable (with βTub60D¹)

(Dettman et al., 1996)

viable (with βTub60D¹⁰)

(Dettman et al., 1996)

viable (with βTub60D^P126)

(Dettman et al., 1996)

viable (with βTub60D^sk)

(Dettman et al., 1996)

visible | recessive

(Kimble et al., 1990)

Phenotype Manifest In

adult optic lobe (with βTub60D¹)

(Hoyle et al., 2000)

eye (with βTub60D¹)

(Hoyle et al., 2000)

lamina (with βTub60D¹)

(Hoyle et al., 2000)

medulla & axon (with βTub60D¹)

(Hoyle et al., 2000)

photoreceptor cell R7 & axon (with βTub60D¹)

(Hoyle et al., 2000)

photoreceptor cell R8 & axon (with βTub60D¹)

(Hoyle et al., 2000)

rhabdomere (with βTub60D¹)

(Hoyle et al., 2000)

Detailed Description

Statement

Reference

In βTub60D¹/βTub60D⁴ brains, there are defects in axonal targeting, spatial positioning and morphology of βTub60D expressing structures in the eye, optic lobe. Mistargeting of R7, 8 and other axons is seen, these axons are also mispositioned within the optic lobe, in a lobe autonomous fashion. Other axons in the optic are affected in this manner. The morphology of the medulla is also abnormal. The lamina exhibit some degree of disorganisation. βTub60D¹/βTub60D⁴ brains exhibit defects in the spatial positioning of the R7,8 axon array. In the adult eye of βTub60D¹/βTub60D⁴ flies, individual rhabdomeres are sometimes missing or defective.