FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\βTub60D2
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General Information
Symbol
Dmel\βTub60D2
Species
D. melanogaster
Name
FlyBase ID
FBal0000021
Feature type
allele
Associated gene
Dmel\βTub60D
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Dettman et al., 2001)
Mutagen
ethyl methanesulfonate
(Dettman et al., 1996, Kimble et al., 1990)
Progenitor genotype
Cytology
Description

No lesions are detectable by sequencing in the βTub60D coding region.

(Dettman et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos develop a body wall musculature that appears normal. The gut elongates and forms gut constrictions in the mutant embryos and the visceral muscles develop normally.

      (Rudolf et al., 2012)

      Lethality acts in the first larval instar. Mutant larvae show overall normal morphology of chordotonal organs, but microtubules show a tendency to cross link that exceeds that of wild type larvae. Overall morphology of Bolwig's organ and nerve are normal in mutant larvae. Wild type foraging larvae show strong tendency towards photonegativity in a "Darth Vader" light avoidance assay. Homozygous mutants are less photonegative and hemizygous mutants are photoneutral.

      (Dettman et al., 2001)

      Homozygotes have morphologically abnormal midguts. Larvae are capable of filling the gut and excreting, but absorption of nutrients is defective.

      (Dettman et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      The observed lethality of homozygous βTub60D2 larvae is likely not due to the mutation in the βTub60D gene, but due to a second site mutation.

      (Rudolf et al., 2012)
      Comments
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      B3t2
      (Dettman et al., 1996)
      β3t2
      (Rudolf et al., 2012)
      βTub60D2
      (Rudolf et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)