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General Information
Symbol
Dmel\abd-AD24
Species
D. melanogaster
Name
FlyBase ID
FBal0000080
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
iab-2D24, abdAD24
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Point mutation.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

lch5 chordotonal organs are frequently mislocalised to the dorsal side of abd-AD24 mutant embryos. These mislocalised chordotonal organs lack ligament attachment cells.

The LCh5 neurons are abnormal in homozygous embryos, and are rarely found in a lateral or dorso-lateral position. The LCh5 neurons exhibit a DCh3-like morphology in abd-AD24 hthdtl-S142204 double mutant embryos and are positioned laterally in 17-19% of abdominal segments.

Cuticle preparations of embryos heterozygous with abd-AD24 show transformations of abdominal segments towards an A1 identity.

Two posterior midgut constrictions fail to form.

First instar larvae exhibit lateral dots (a paired structure found in A1 segment of wild type) in abdominal segment A2 to A5 and rarely in A6.

Hemizygous embryonic phenotype displays complete transformation of abdominal parasegments 7, 8 and 9 into parasegment 6 and partial transformation of abdominal parasegments 10 to 13 into parasegment 6 (FBrf0043314).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Ubx1, abd-AD24, Abd-BD18 triple mutant embryos show a significantly increased proportion of mitotic neuroblasts in the A9-10 ventral nerve cord segments, and a significantly increased proportion of mitotic neuroblast daughter cells in the A1, A8 and A9-10 ventral nerve cord segments, as compared to controls.

Dp(3;2)D109; abd-AD24, Abd-BD18/Df(3R)Ubx-RS4-8 males are phenotypically indistinguishable from Abd-BD18/Df(3R)Ubx-RS4-8 males in abdominal segmentation and show A5 and A6 identities. Dp(3;2)D109; Ubx1, abd-AD24, Abd-BD18/Df(3R)Ubx-RS4-8 males show A5 and A6 identities while Dp(3;2)D109; Df(3R)RS1-98/Df(3R)Ubx-RS4-8 lack A5 and A6 identities.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

Duncan.

I. Duncan.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (20)