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General Information
Symbol
Dmel\Abd-BD18
Species
D. melanogaster
Name
FlyBase ID
FBal0044547
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
AbdBD18
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Deleted for BX-C between +163.5-166.5 and 148.5-150, i.e. breaks fall in both the complete and the duplicated section of Abd-B region. Lacks the 9kb EcoRI fragment diagnostic of Abd-BMc.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Abd-BD18 mutant embryos show a significant increase in the number of (Dpn-positive) neuroblasts in the ventral nerve cord segments A9-10, show a significantly increased mitotic index of neuroblasts in the ventral nerve cord segments A9-10 and show significantly increased mitotic index of neuroblast daughter cell in the ventral nerve cord segments A8, as compared to controls.

Mutant embryos generate an additional cluster of eve positive mesodermal cells in PS 13. Supernumerary cardioblasts are also seen in the heart portion of the dorsal vessel of late stage embryos: about 116 cardioblast nuclei are seen as opposed to 104 in the wild-type. The heart in these embryos do not appear to be significantly elongated, it is frequently much wider and extra cardioblasts are arranged in irregular clusters or double-rows within its posterior portion. The somatic muscles in abdominal segment 8 in mutant embryos show an increase in the number of nuclei, and a pattern that is more similar to that normally found in A7.

Heterozygous flies show no transformation of A7 towards A6. The phenotype of abdominal segment 6 is similar in Abd-BFab7-1/Abd-BD18 and Abd-BFab7-1/+ flies.

Heterozygotes with Df(3R)Ubx-RS4-8 or Df(3R)Abd-BS10 have partial transformation of A5-7 to more anterior character: A7 forms tergite, like A6 in the WT; A6 resembles A5 in having more trichome covered area than WT A6 ; A5, which is fully pigmented in the WT, is, like WT A4, only partially pigmented. Dp(3;2)D109; abd-AD24, Abd-BD18/Df(3R)Ubx-RS4-8 and Dp(3;2)D109; abd-AH10.7, Abd-BD18/Df(3R)Ubx-RS4-8 males are phenotypically indistinguishable from Abd-BD18/Df(3R)Ubx-RS4-8 males in abdominal segmentation and show A5 and A6 identities. Dp(3;2)D109; Ubx1, abd-AD24, Abd-BD18/Df(3R)Ubx-RS4-8 males show A5 and A6 identities while Dp(3;2)D109; Df(3R)RS1-98/Df(3R)Ubx-RS4-8 lack A5 and A6 identities.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT suppressed by
Statement
Reference
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Ubx1, abd-AD24, Abd-BD18 triple mutant embryos show a significantly increased proportion of mitotic neuroblasts in the A9-10 ventral nerve cord segments, and a significantly increased proportion of mitotic neuroblast daughter cells in the A1, A8 and A9-10 ventral nerve cord segments, as compared to controls.

The transformation of genitalia into leg seen in Abd-BD18 mutant clones is still seen in Abd-BD18 AntpNs-rvC3 double mutants.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially complements
Comments
Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer

Revertant. Revertant of the Abd-BMc microcephalus phenotype.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (18)