FB2026_02 , released June 18, 2026
Allele: Dmel\Adhn11
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General Information
Symbol
Dmel\Adhn11
Species
D. melanogaster
Name
FlyBase ID
FBal0000342
Feature type
allele
Associated gene
Dmel\Adh
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Hollocher and Place, 1987)

hypomorphic allele - genetic evidence

Mutagen
ethyl methanesulfonate
(Thatcher, 1980)
Progenitor genotype
AdhF
(Chenevert et al., 1995, Hollocher and Place, 1987, Thatcher, 1980)
Cytology
Description

Amino acid replacement: G15D. Nucleotide substitution: G821A.

(Chenevert et al., 1995)

Mutation in adenine ribose pocket of coenzyme binding domain; is not bound to 5'-AMP sepharose and cannot recognize NAD+.

(Thatcher and Retzios, 1980)

Amino acid replacement: G14D.

(Thatcher, 1980)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:14,616,382..14,616,382 [+]
Nucleotide change:

G14616382A

Reported nucleotide change:

G821A

Amino acid change:

G15D | Adh-PC; G15D | Adh-PE; G15D | Adh-PF; G15D | Adh-PH; G15D | Adh-PI

Reported amino acid change:

G15D

Comment:

Induced on an AdhF@ chromosome.

(Chenevert et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adhn6/Adhn11 heterozygotes display partial resistance to alcohol; hybrid enzyme activity heat labile.

      (Pelliccia and Sofer, 1982)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (5)
      Notes on Origin
      Discoverer

      Sofer.

      Selected as: Pentenol resistant larva.

      Comments
      Comments

      Enzyme activity: 0.02% of wild type progenitor. CRM: 27% of wild type progenitor.

      Product forms activer heterodimer with: AdhF that migrates as AdhF/AdhUF.

      (Schwartz and Jornvall, 1976)

      Protein has ultra fast electrophoretic mobility.

      (Thatcher, 1980)

      Product displays altered substrate binding properties.

      (Pelliccia and Sofer, 1982)

      Product forms active heterodimer with: AdhF, AdhS and AdhD.

      (Hollocher and Place, 1987)

      Used, carried in P-element vectors along with other Adh alleles, to study gene conversion and unequal crossing over to re-generate "Adh+".

      (Hipeau-Jacquotte et al., 1989)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AdhN-11
      (Thatcher, 1980)
      Adhn11
      Name Synonyms
      Secondary FlyBase IDs
        References (15)