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General Information
Symbol
Dmel\BicC5
Species
D. melanogaster
Name
FlyBase ID
FBal0001139
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
BicCYC33, Bic-CYC33
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

BicC5/Df(2L)RA5 adults show reduced survival rate (while BicC5/+ heterozygotes survive normally) and display deformations of their Malpighian tubules (disorganization of the tubular epithelial cells, large, often numerous cysts, extra branching) from an early age. These abnormal enlargements (cysts) are filled with fluid and contain dark crystalline particles. The cyst formation appears to increase over time and by day 30 the mutant flies display multiple cysts in both tubules and prominent deformities of the anterior terminal tubule. BicC5/Df(2L)RA5 mutants survive worse under high-salt diet stress conditions compared to wild-type, although they feed on it normally.

Cysts are also observed in BicC5 homozygous adults and the tubules appear enlarged with irregular distribution of principal cell nuclei.

15% of embryos derived from heterozygous female hatch. Of the non-hatching embryos, 60% are bicaudal and 14% have head defects.

Phenotypically wild type embryos from heterozygous mothers localize vas protein normally throughout embryogenesis. In phenotypically bicaudal embryos the pole cells fail to coalesce into gonads.

Strong BicC allele.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The Malpighian tubules deformities characteristic for BicC5 homozygous mutant adults are partially rescued by expression of either MycJF01762 or MycJF01761 (leads to weaker rescue) under the combined control of Scer\GAL4c42 and Scer\GAL4tsh-c724 drivers: the incidence of cysts is significantly reduced in the terminal and in the proximal tubule, the tubular swelling and the irregular distribution of cell nuclei is also reduced compared to controls.

72% of embryos derived from BicC5/aretQB females hatch. 65% of embryos derived from BicC5/+ ; orbmel/+ females hatch. Of the non-hatching embryos, 39% are bicaudal and 52% have head defects. 30% of embryos derived from BicC5/+ ; orbF303/+ females hatch. Of the non-hatching embryos, 62% are bicaudal and 30% have head defects. 87% of embryos derived from BicC5/+ ; orbF343/+ females hatch.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

C. Nusslein-Volhard.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (15)