Mutant third instar larvae have melanotic nodules found in the hemocoel or in association with He-positive lymph glands. They also show gut melanisation not accompanied by tissue overgrowth or hemocyte encapsulation.
Strong ventralizing phenotype: lack of all dorsally and laterally derived structures and the expansion of the ventral epidermis around the entire circumference. Expansion of twi expression in terminal regions.
cact4/cact[+], Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of increased cell death phenotype of Hsap\CHMP2BIntron5.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
cact4/cact[+], Scer\GAL4GMR.PF/Scer\GAL4GMR.PF is an enhancer of eye phenotype of Hsap\CHMP2BIntron5.UAS, Scer\GAL4GMR.PF/Scer\GAL4GMR.PF
cact4/cact1 is a non-enhancer of embryo | ventral phenotype of Scer\GAL4VP16.nos.UTR, wntDUAS.cGa
wntDScer\UAS.cGa,Scer\GAL4nos.UTR.T:Hsim\VP16 cact4/cact1 mutant embryos exhibit a strongly dorsalised phenotype identical to wntDScer\UAS.cGa,Scer\GAL4nos.UTR.T:Hsim\VP16 alone.
The presence of a copy of cact4 significantly enhances the Hsap\CHMP2BIntron5.Scer\UAS Scer\GAL4GMR.PF phenotype.