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FB2021_03, released June 15, 2021

Allele: Dmel\cact4

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General Information
Symbol
Dmel\cact4
Species
D. melanogaster
Name
FlyBase ID
FBal0001510
Feature type
allele
Associated gene
Dmel\cact
Associated Insertion(s)
Carried in Construct
Also Known As
cactG8
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Ashburner et al., 1999.10.12, Roth et al., 1991, Tearle and Nusslein-Volhard, 1987)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cact4/Df(2L)r10, cact4/Df(2L)cact-255rv64 and cact1/cact4 larvae do not show R2-R5 photoreceptor axon targeting defects in the developing visual system.

      (Minidorff et al., 2007)

      Mutant third instar larvae have melanotic nodules found in the hemocoel or in association with He-positive lymph glands. They also show gut melanisation not accompanied by tissue overgrowth or hemocyte encapsulation.

      (Minakhina and Steward, 2006)

      cact1/cact4 mutant embryos exhibit a strong ventralised phenotype.

      (Gordon et al., 2005)

      Strong ventralizing phenotype: lack of all dorsally and laterally derived structures and the expansion of the ventral epidermis around the entire circumference. Expansion of twi expression in terminal regions.

      (Roth et al., 1991)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Suppressor of
      Statement
      Reference

      cact4/cact[+] is a suppressor of visible | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      Phenotype Manifest In
      Enhancer of
      NOT Enhancer of
      Statement
      Reference

      cact4/cact1 is a non-enhancer of embryo | ventral phenotype of Scer\GAL4VP16.nos.UTR, wntDUAS.cGa

      (Gordon et al., 2005)
      Suppressor of
      Statement
      Reference

      cact4/cact[+] is a suppressor of eye | heat sensitive phenotype of peb1

      (Wilk et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      wntDScer\UAS.cGa,Scer\GAL4nos.UTR.T:Hsim\VP16 cact4/cact1 mutant embryos exhibit a strongly dorsalised phenotype identical to wntDScer\UAS.cGa,Scer\GAL4nos.UTR.T:Hsim\VP16 alone.

      (Gordon et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference

      The presence of a copy of cact4 significantly enhances the Hsap\CHMP2BIntron5.Scer\UAS Scer\GAL4GMR.PF phenotype.

      (Ahmad et al., 2009)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (9)