FlyBase Allele Report: Dmel\Pka-R2[Cos-A1]

General Information

Symbol

Dmel\Pka-R2^Cos-A1

Species

D. melanogaster

Name

FlyBase ID

FBal0001792

Feature type

allele

Associated gene

Dmel\Pka-R2

Associated Insertion(s)

Carried in Construct

Also Known As

Cos-1^A1

Key Links

Allele class

neomorphic allele - genetic evidence

Mutagen

gamma ray

Nature of the Allele

Allele class

neomorphic allele - genetic evidence

(Grau and Simpson, 1987)

Mutagen

gamma ray

(Lindsley and Zimm, 1992, Grau and Simpson, 1987)

Progenitor genotype

Caused by aberration

In(2R)Pka-R2^Cos-A1

Cytology

Polytene chromosomes normal.

(Grau and Simpson, 1987)

Description

Encodes a mutant transcript which contains the third exon of Pka-R2 (this includes the ATG) but lacks the first and second exons of wild-type Pka-R2. Sequence from the 14-3-3ζ and Jra genes (which are normally located approximately 100kb distal to Pka-R2) are present in place of the missing exons. The sequence of the mutant transcript is consistent with the underlying aberration being an inversion.

(Collier et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Lindsley and Zimm, 1992, Grau and Simpson, 1987)

viable (with Pka-R2^Cos-A1R+1A)

(Grau and Simpson, 1987)

Phenotype Manifest In

haltere

(Grau and Simpson, 1987)

wing

(Grau and Simpson, 1987)

Detailed Description

Statement

Reference

Class I allele; homozygous viable and displays pattern duplications in both heterozygotes and homozygotes.

(Lindsley and Zimm, 1992)

Local pattern duplications of wing and haltere.

(Grau and Simpson, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Pka-R2^Cos-A1, cos[+]/cos^V1 has visible | dominant phenotype

(Collier et al., 2004)

Pka-R2^Cos-A1/Pka-R2[+], cos^V1 has visible phenotype

(Collier et al., 2004)

Pka-C1^Cos-1, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-2, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E13, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E14, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E15, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E16, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E18, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E19, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E2, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E20, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E3, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E4, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-2R+1, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E5, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E6, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E9, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-4, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-8, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-9, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-R2^Cos-A1, cos^V1 has lethal | maternal effect | embryonic stage phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-R2^Cos-A1, cos^V3 has lethal | maternal effect | embryonic stage phenotype

(Grau and Simpson, 1987)

Pka-R2^Cos-A1, cos^V2 has lethal | maternal effect | embryonic stage phenotype

(Grau and Simpson, 1987)

Pka-R2^Cos-A1, cos^V4 has lethal | maternal effect | embryonic stage phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+2, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Df(2R)CA58, Pka-R2^Cos-A1 has partially lethal - majority live phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+4, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E1, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E10, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E11, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Pka-C1^Cos-3R+E12, Pka-R2^Cos-A1 has viable phenotype

(Grau and Simpson, 1987)

Phenotype Manifest In

Other

Statement

Reference

Pka-R2^Cos-A1, cos[+]/cos^V1 has wing phenotype

(Collier et al., 2004)

Pka-R2^Cos-A1, cos[+]/cos^V1 has double row of wing sensilla | ectopic phenotype

(Collier et al., 2004)

Pka-R2^Cos-A1, cos[+]/cos^V1 has costal wing cell phenotype

(Collier et al., 2004)

Pka-R2^Cos-A1, cos[+]/cos^V1 has triple row of wing sensilla | ectopic phenotype

(Collier et al., 2004)

Pka-R2^Cos-A1, cos^V1 has wing phenotype

(Collier et al., 2004)

Pka-R2^Cos-A1, cos^V1 has double row of wing sensilla | ectopic phenotype

(Collier et al., 2004)

Pka-R2^Cos-A1, cos^V1 has costal wing cell phenotype

(Collier et al., 2004)

Pka-R2^Cos-A1, cos^V1 has triple row of wing sensilla | ectopic phenotype

(Collier et al., 2004)

Df(2R)CA58, Pka-R2^Cos-A1 has wing phenotype

(Grau and Simpson, 1987)

Additional Comments

Genetic Interactions

Statement

Reference

cos^V1 Pka-R2^Cos-A1 double heterozygotes show a large duplication of the costa region in the wing. The duplication contains triple-row and double-row bristles, indicating it consists of anterior structures.

(Collier et al., 2004)

Wings are duplicated when transheterozygous with Df(2R)CA58 (cos^-). In flies also mutant for en¹, duplications only occur in the original anterior compartment, and not in the transformed posterior compartment, indicating that the duplications develop as a position response. The phenotype of embryos resulting from crosses involving viable alleles of cos and Pka-R2^Cos-A1 indicate a maternal effect on the interaction between Pka-R2 and cos. If the female parent is heterozygous for a viable allele of cos and Pka-R2^Cos-A1, and the male parent for Pka-R2^Cos-A1, 11% of the embryos show a strong bicaudal phenotype (whereas the reciprocal cross produces less than 1% bicaudal embryos). In Pka-R2^Cos-A1, en¹ double mutants the duplications characteristic of Pka-R2^Cos-A1 only occur in the original anterior compartment, and not in the transformed posterior compartment, indicating that the Pka-R2^Cos-A1 duplications develop as a position response.

(Grau and Simpson, 1987)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Complements

Pka-R2^Cos-A1R+1A

(Grau and Simpson, 1987)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

M. Ashburner.

(Grau and Simpson, 1987)

Harrington.

(Lindsley and Zimm, 1992)

Separable from: In(2L)Epa. In(2L)Epa was induced simultaneously with Pka-R2^Cos-A1 but subsequently the two were separated by recombination.

(Grau and Simpson, 1987)

Comments

Penetrance and expressivity are variable. The pattern duplications seen in flies heterozygous for neomorphic "Cos" alleles are indistinguishable from those seen in flies homozygous for leaky alleles of cos.

(Grau and Simpson, 1987)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Cos-1^A1

(Grau and Simpson, 1987, Simpson and Grau, 1987)

Cos1^A1

(Collier et al., 2004, Collier et al., 2002)

Cos¹⁰

(Lindsley and Zimm, 1992)

Epa

Pka-R2^Cos-A1

pka-RII^Cos1A1

(Collier et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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