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General Information
Symbol
Dmel\da1
Species
D. melanogaster
Name
FlyBase ID
FBal0002214
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Insertion of a 1360 element.

900 bp insertion of middle repetitive DNA in untranslated leader.

Insertion components
1360{}da1
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Only male progeny are recovered from da1/dak08611 females.

Homozygotes survive at 18oC and die at 25oC. da1 homozygous embryos lacking maternal and zygotic da have defects in mesodermal development. The mesoderm migrates properly, however, further mesodermal development is impaired. Somatic muscle development is severely suppressed, embryos have reduced numbers of aberrantly placed syncitial muscles. Heart development is also repressed.

Does not interact with Sxldlf, fl(1)3535 or fl(1)3546.

Homozygous females have no female offspring due to failure to properly regulate the Sxl gene in the zygote.

At the restrictive temperature (25oC) less than 1% of females derived from homozygous mothers eclose. At the permissive temperature (18oC) the viability of these females derived from homozygous mothers is 100%.

Sxlf1 heterozygous female progeny derived from heterozygous da1 mothers have reduced viability. The viability is increased if the Sxlf1/+ progeny are also carrying msl-31, and is decreased if the da1/+ mothers are also carrying msl-31. The frequency of sex transformation in Sxlf1/+ female progeny derived from da1/+ mothers is increased if either the mothers or the progeny are homozygous for msl-31. The frequency of morphological abnormalities seen in Sxlf1/+ female progeny derived from da1/+ mothers is greatly reduced if the progeny are also homozygous for msl-31.

Homozygous females when mated to any male produce normal sons but no daughters. Otherwise, da mutant cannot be distinguished from wild type.

(=da); viable; temperature-sensitive hypomorph; strong daughterless maternal effect above 22oC; lethal with Df or amorphic alleles; lethal at 29oC

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

da1 has lethal | female phenotype, suppressible by dpn[+]/dpn3

da1 has lethal | female phenotype, suppressible by dpn[+]/dpn4

da1 has lethal | female phenotype, suppressible by dpn5/dpn[+]

da1 has lethal | female phenotype, suppressible by dpn[+]/dpn6

da1 has lethal | female phenotype, suppressible by dpn7/dpn[+]

Phenotype Manifest In
Enhanced by
Statement
Reference

da1 has phenotype, enhanceable by E(da)1

Enhancer of
Statement
Reference

da1/da[+] is an enhancer of eye | heat sensitive phenotype of Df(3R)p13/ato1090

da1/da[+] is an enhancer of photoreceptor cell | heat sensitive phenotype of Df(3R)p13/ato1090

Additional Comments
Genetic Interactions
Statement
Reference

A da1 heterozygous background gives a dominant moderate enhancement to the ato1090/Df(3R)p13 eye phenotype at 25[o]C.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Lethality of da2/da1 can be rescued by dahs.PSP, and females show same follicular phenotype as das22/da7.

Images (0)
Mutant
Wild-type
Stocks (3)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
References (34)