FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dpn6
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General Information
Symbol
Dmel\dpn6
Species
D. melanogaster
Name
FlyBase ID
FBal0049432
Feature type
allele
Associated gene
Dmel\dpn
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Barbash and Cline, 1995)
Mutagen
gamma ray
(Barbash and Cline, 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: N61I. Amino acid replacement: L63R. N61 and L63 fall in helix I of the bHLH region. Nucleotide substitution: A451T and T457G (nucleotide positions as in cDNA sequence of FBrf0056120).

(Barbash and Cline, 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:8,231,639..8,231,639 [-]
Nucleotide change:

A8231639T

Reported nucleotide change:

A451T

Amino acid change:

N61I | dpn-PA

Reported amino acid change:

N61I.

Comment:

1st of two single nucleotide changes in mutant

(Barbash and Cline, 1995)
point_mutation
2R:8,231,633..8,231,633 [-]
Nucleotide change:

T8231633G

Reported nucleotide change:

T457G

Amino acid change:

L63R | dpn-PA

Reported amino acid change:

L63R

Comment:

2nd of two single nucleotide changes in mutant

(Barbash and Cline, 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      dpn-mediated suppression of sisA female lethality is entirely zygotic. May be cell lethal in germ-line clones.

      (Barbash and Cline, 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      dpn[+]/dpn6 is an enhancer of visible | dominant phenotype of N55e11

      (Babaoğlan et al., 2013)
      Suppressor of
      Statement
      Reference

      dpn[+]/dpn6 is a suppressor of lethal | female phenotype of da1

      (Barbash and Cline, 1995)

      dpn[+]/dpn6 is a suppressor of lethal | female phenotype of scsisB-1

      (Barbash and Cline, 1995)

      dpn[+]/dpn6 is a suppressor of lethal | female phenotype of sisA1

      (Barbash and Cline, 1995)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      dpn[+]/dpn6 is an enhancer of wing margin phenotype of N55e11

      (Babaoğlan et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      dpn6/+ enhances the wing notching phenotype seen in N55e11/+ flies (97% of flies have wing nicks).

      (Babaoğlan et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Functionally a null allele. Viability over deficiencies for dpn is two- to three-fold lower than for dpn3, dpn4 or dpn5. Viability of dpn1/dpn6 is unexpectedly high, perhaps due to transvection between the alleles. Complementation between mutant dpn alleles reveals differences in strength but little male-specific lethality.

      (Barbash and Cline, 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dpn6
      (Córdoba and Estella, 2014, Babaoğlan et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)