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General Information
Symbol
Dmel\Dfd12
Species
D. melanogaster
Name
FlyBase ID
FBal0002385
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
Dfdr11, EbR11, DfdrR11
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

T6792954A

Reported nucleotide change:

T?A

Amino acid change:

Y210term | Dfd-PA

Reported amino acid change:

Y210term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology

Polytene chromosomes normal.

Nature of the lesion
Statement
Reference

Amino acid replacement: Y210term.

Nucleotide substitution: T?A.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Stage 12 Dfd16/Dfd12 embryos show displacement of the maxillary segment and mandibular segments due to an accumulation of supernumerary cells at the ventral side of both segments. Cells in the ventral part of the maxillary segment are elongated, instead of round like wild-type cells.

In Dfd12/Dfd16 embryos, the maxillary cirri primordium and the anterior boundary of the dorsal ridge, between the mandibular and maxillary segments, are missing. The number of apoptotic cells in the maxillary segment is reduced when compared to wild-type.

Dfd12/Df(3R)Scr embryos lack the mouthhooks and cirri, while the more posterior mouthparts are unaffected. The mouthhook and cirri defects are rescued in Dfd12/Df(3R)Scr embryos expressing DfdScer\UAS.cBa under the control of Scer\GAL469B. Head involution fails in these animals and the posterior mouthparts fail to form. Dfd12/Dfd16 embryos lack the mouthhooks and cirri, while the more posterior mouthparts are unaffected.

Mouth hook material is in a position posterior to wild type and rarely possess maxillary cirri: defects in structures derived from the maxillary, mandibular and premandibular regions of the embryonic head. Mitotic recombination analysis suggests that in the adult Dfd affects the head structures homologous to those of the embryo.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

The mouthhook and cirri defects are rescued in Dfd12/Dfd16 embryos expressing Tcas\DfdScer\UAS.cBa under the control of Scer\GAL469B. Head involution fails in these animals and the posterior mouthparts fail to form.

Complementation and Rescue Data
Partially rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

R. Lewis.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
References (12)