Open Close
General Information
Symbol
Dmel\dl5
Species
D. melanogaster
Name
FlyBase ID
FBal0002647
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

G17442287A

Amino acid change:

V188M | dl-PA; V188M | dl-PB; V188M | dl-PC; V188M | dl-PD; V188M | dl-PE; V188M | dl-PF

Reported amino acid change:

V188M

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Val to Met substitution at amino acid 188, within the amino terminal half.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

When in trans with Df(2L)TW119 the transgene P{Dipt2.2-lacZ} is not induced.

Strong dorsalization: loss of ventral epidermis.

Weak dorsal phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Expression of Tcas\dlScer\UAS.cCa under the control of Scer\GAL4mat.alphaTub67C.T:Hsim\VP16 partially suppresses dl5/Df(2L)TW119. One copy of the transgene leads to differentiation of dorsolateral structures (e.g. filzkorper); two copies promote, in addition, the formation of ventrolateral structures (e.g. ventral epidermis).

Complementation and Rescue Data
Comments

Expression of dlScer\UAS.cCa under the control of Scer\GAL4mat.alphaTub67C.T:Hsim\VP16 completely suppresses the dl5/Df(2L)TW119 phenotype, sometimes even to the point of ventralisation.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (6)