FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dl27
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General Information
Symbol
Dmel\dl27
Species
D. melanogaster
Name
FlyBase ID
FBal0002669
Feature type
allele
Associated gene
Dmel\dl
Associated Insertion(s)
Carried in Construct
Also Known As
dlD7
Key Links
Genomic Maps

Allele class

antimorphic allele - genetic evidence

hypomorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

antimorphic allele - genetic evidence

(Isoda et al., 1992)

hypomorphic allele - genetic evidence

(Lemaitre et al., 1995)

loss of function allele

(Bergmann et al., 1996)
Mutagen
ethyl methanesulfonate
(Szabad et al., 1989)
gamma ray
(Szabad et al., 1989)
Progenitor genotype
Cytology
Description

Arg to Cys substitution at amino acid 63, within the amino terminal half.

(Isoda et al., 1992)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:17,442,800..17,442,800 [-]
Nucleotide change:

C17442800T

Amino acid change:

R63C | dl-PA; R63C | dl-PB; R63C | dl-PC; R63C | dl-PD; R63C | dl-PE; R63C | dl-PF

Reported amino acid change:

R63C

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Isoda et al., 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      When in trans with Df(2L)TW119 the transgene P{Dipt2.2-lacZ} is not induced.

      (Lemaitre et al., 1995)

      Causes complete dorsalization of embryo when heterozygous with a deficiency of dl.

      (Isoda et al., 1992)

      Embryos derived from heterozygous females have a range of phenotypes, from a disarranged head skeleton to a "tail-up" phenotype.

      (Szabad et al., 1989)

      dominant

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      dl27 is rescued by dlHsp83.PG

      (Govind et al., 1992)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dl27
      dlD7
      (Bergmann et al., 1996, Gross et al., 1996, Lemaitre et al., 1995, Isoda et al., 1992, Szabad et al., 1989)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)