FB2026_02 , released June 18, 2026
Allele: Dmel\Gpdh1nSP10
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General Information
Symbol
Dmel\Gpdh1nSP10
Species
D. melanogaster
Name
FlyBase ID
FBal0005189
Feature type
allele
Associated gene
Dmel\Gpdh1
Associated Insertion(s)
Carried in Construct
Also Known As
nsp10
Key Links
Genomic Maps

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Davis and MacIntyre, 1988)

loss of function allele

(Wojtas et al., 1997)
Mutagen
ethyl methanesulfonate
(Wojtas et al., 1997, Davis and MacIntyre, 1988)
Progenitor genotype
Gpdh1B
Cytology
Description

Nucleotide substitution: G?A.

(Carmon et al., 2010)

Amino acid replacement: W15term.

(Carmon et al., 2010)

Amino acid replacement: ?12term.

(Sullivan et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:5,944,268..5,944,268 [+]
Nucleotide change:

G5944268A

Reported nucleotide change:

G?A

Amino acid change:

W15term | Gpdh1-PA; W15term | Gpdh1-PB; W15term | Gpdh1-PC; W15term | Gpdh1-PE; W15term | Gpdh1-PF; W15term | Gpdh1-PG

Reported amino acid change:

W15term

(Carmon et al., 2010)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Relative viability decreases as the genotype approaches the homozygous Gpdh-/Gpo- double null state: phenotype ranges from flightless and viable to lethal. Double null combination with Gpon322 produces few viable progeny over the double deletion Df(2L)cl7 Df(2R)WMG chromosome.

      (Davis and MacIntyre, 1988)

      CRM by immunoprecipitation: ++ % wildtype enzyme activity: 9.2 relative enzyme mobility: <GpdhB relative viability: 0.95 can fly

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Gpdh1nSP10/Df(2L)cl7 is partially rescued by Gpdh1hs.PC

      (Carmon et al., 2010)
      Comments

      Expression of Gpdhhs.PC partially rescues the impaired flight ability of GpdhnSP10/Df(2L)cl7 animals.

      (Carmon et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      CRM- mutant.

      (Wojtas et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Gpdh1nSP10
      GpdhSP10
      (Davis and MacIntyre, 1988)
      GpdhnSP10
      nsp10
      (Carmon et al., 2010, Sullivan et al., 2003, Wojtas et al., 1997)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)