FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ns3A60
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General Information
Symbol
Dmel\Ns3A60
Species
D. melanogaster
Name
FlyBase ID
FBal0006633
Feature type
allele
Associated gene
Dmel\Ns3
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
Progenitor genotype
Cytology
Description

8bp deletion (TAAAGGAG) in the second exon. This is predicted to produce a frameshift after 198 of the 606 amino acids, followed by three missense codons and a premature stop. The truncated protein would not contain the putative GTP-binding domain.

(Hartl et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:1,463,439..1,463,446 [-]
Comment:

8 bp deletion causes a frameshift after 198 aa.

(Hartl et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ns3G0431/Ns3A60 males show 100% lethality, while females show 22.4% viability. The surviving females eclose later than their heterozygous siblings, are smaller than normal and have slender bristles mimicking the Minute phenotype.

      (Hartl et al., 2013)

      L1 larval lethal

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Ns3G0431

      (Hartl et al., 2013)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Lefevre.

      Comments
      Comments

      Maternal germline clonal analysis demonstrates cell lethality in homozygous clones.

      (Perrimon et al., 1989)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      A60
      (Perrimon et al., 1989)
      Ns3A60
      l(1)2Ad1
      (Hartl et al., 2013)
      l(1)A60
      ns3l(1)2Ad1
      (Hartl et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)