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Citation
Hartl, T.A., Ni, J., Cao, J., Suyama, K.L., Patchett, S., Bussiere, C., Gui, D.Y., Tang, S., Kaplan, D.D., Fish, M., Johnson, A.W., Scott, M.P. (2013). Regulation of ribosome biogenesis by nucleostemin 3 promotes local and systemic growth in Drosophila.  Genetics 194(1): 101--115.
FlyBase ID
FBrf0221450
Publication Type
Research paper
Abstract

Nucleostemin 3 (NS3) is an evolutionarily conserved protein with profound roles in cell growth and viability. Here we analyze cell-autonomous and non-cell-autonomous growth control roles of NS3 in Drosophila and demonstrate its GTPase activity using genetic and biochemical assays. Two null alleles of ns3, and RNAi, demonstrate the necessity of NS3 for cell autonomous growth. A hypomorphic allele highlights the hypersensitivity of neurons to lowered NS3 function. We propose that NS3 is the functional ortholog of yeast and human Lsg1, which promotes release of the nuclear export adapter from the large ribosomal subunit. Release of the adapter and its recycling to the nucleus are essential for sustained production of ribosomes. The ribosome biogenesis role of NS3 is essential for proper rates of translation in all tissues and is necessary for functions of growth-promoting neurons.

PubMed ID
PubMed Central ID
PMC3632458 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference