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General Information
Symbol
Dmel\Dcp-102132
Species
D. melanogaster
Name
FlyBase ID
FBal0007995
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
dcp-12132
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Contains a 40bp partial P element insertion in the coding region of Dcp-1 and an in-frame stop codon within the 40bp insertion.

The P{PZ}Dcp-102132 insertion affects both Dcp-1 and pita, which have overlapping transcription units.

P{PZ} is inserted into the first exon of Dcp-1.

Insertion components
P{PZ}Dcp-102132
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Dcp-102132 mutant fat bodies display robustly induced autophagy in fed larvae, higher than in wild-type. The level of autophagy is increased upon starvation.

Mutant embryos show no abnormalities in the pattern of cell death.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer

A. Spradling.

Comments
Comments

Complements: chrwk06908. Complements: aptk15608. Complements: l(2)s4830s4830.

P{PZ}Dcp-102132 disrupts both Dcp-1 and pita. Several phenotypes that were originally attributed to loss of Dcp-1 in the P{PZ}Dcp-102132 line, including melanotic tumors, small imaginal discs, and dumpless egg chambers, have since been shown to be due to disruption of pita (see FBrf0167648).

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (13)