crol⁰⁴⁴¹⁸/+ suppresses position effect variegation at the w locus caused by P{SUPor-P}KV00108.

Homozygotes survive through embryogenesis and hatch to form first instar larvae. Homozygous larvae progress normally through prepupal development, showing no delay in puparium formation, but die before adult eclosion. Homozygotes die during two stages of pupal development. The first lethal phase occurs at the beginning of pupal development, during stage P5. Pupae that arrest at this stage have severe defects in head eversion and leg elongation. Approximately 40-50% of homozygotes die at stage P14, at the end of pupal development, with a microcephalic phenotype and malformed legs. The penetrance of the microcephalic phenotype is variable, while the "crooked legs" phenotype is highly penetrant and similar in all legs examined. The third pair of legs are smaller than wild-type, have a kink near the middle of the femur and lack some bristles in hemizygotes. Hemizygous leg discs show a range of defects from partial elongation to severe malformation. Legs showing partial elongation also have slightly more expanded 2nd to 5th tarsal segments compared to wild-type legs. Imaginal discs are normal in size and morphology.

crol⁰⁴⁴¹⁸ is an enhancer of eye phenotype of Hsap\HTT^{128Q.1-336.UAS}, Scer\GAL4^GMR.PU

crol⁰⁴⁴¹⁸ is an enhancer of wing phenotype of if³