FlyBase Allele Report: Dmel\stc[05441]

General Information

Symbol

Dmel\stc⁰⁵⁴⁴¹

Species

D. melanogaster

Name

FlyBase ID

FBal0008509

Feature type

allele

Associated gene

Dmel\stc

Associated Insertion(s)

P{PZ}stc⁰⁵⁴⁴¹

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Stroumbakis et al., 1996)

Mutagen

P-element activity

(Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12, Spradling et al., 1999, FlyBase, 1996-, Stroumbakis et al., 1996, Roote, 1995.5.4, BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{PZ}stc⁰⁵⁴⁴¹

Cytology

Description

The P{PZ}stc⁰⁵⁴⁴¹ insertion (FBti0005150), is identified as an allele of CG15269 on molecular grounds as well as an allele of stc on genetic grounds.

(FlyBase, 1996-)

Insertion of a P-element in the 5' regulatory region, approximately 2kb upstream of the stc transcription unit.

(Stroumbakis et al., 1996)

Allele components

Component

Use(s)

Inserted element

P{PZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:15,111,587..15,111,587 [+]

(Benito-Sipos et al., 2010, Ashburner et al., 1999, Ashburner et al., 1999, Ashburner et al., 1999.10.12, Spradling et al., 1999, FlyBase, 1996-, Stroumbakis et al., 1996, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Ashburner et al., 1999, Spradling et al., 1999, Roote, 1995.5.15)

lethal - all die during embryonic stage | recessive

(Stroumbakis et al., 1996)

some die during embryonic stage | recessive

(Stroumbakis et al., 1996)

Phenotype Manifest In

Detailed Description

Statement

Reference

The embryonic central nervous system has no obvious abnormalities in homozygotes. Homozygous embryos show little movement within the egg case, fail to hatch and die.

(Stroumbakis et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

11408

P{PZ}stc⁰⁵⁴⁴¹ CG15269⁰⁵⁴⁴¹ cn¹/CyO; ry⁵⁰⁶

Kyoto

130377

P{PZ}stc⁰⁵⁴⁴¹ cn¹ / CyO; ry⁵⁰⁶

Notes on Origin

Discoverer

A. Spradling.

(Roote, 1995.5.4)

Comments

Excision of the P{PZ} element can revert the mutant phenotype.

(Ashburner et al., 1999)

Complements: gft⁰⁶⁴³⁰.

(BDGP Project Members, 1994-1999)

Precise excision of the P-element completely reverts the lethal phenotype.

(Stroumbakis et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

PZ05441

(Ashburner et al., 1999)

PZ9

(Stroumbakis et al., 1996)

l(2)05441

(Spradling et al., 1999)

l(2)35Cb^PZ9

(Roote, 1995.5.15)

stc⁰⁵⁴⁴¹

(Benito-Sipos et al., 2010, Salzer et al., 2010, Jordan et al., 2006, Pasyukova et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (15)

Report Sections

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