FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mcm2rL074
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General Information
Symbol
Dmel\Mcm2rL074
Species
D. melanogaster
Name
FlyBase ID
FBal0011115
Feature type
allele
Associated gene
Dmel\Mcm2
Associated Insertion(s)
P{PZ}Mcm2rL074
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Treisman and Rubin, 1996, Treisman et al., 1995)
Progenitor genotype
Associated Insertion(s)
P{PZ}Mcm2rL074
Cytology
Description

The 5' end of the transcript is 6bp from the P{PZ} element.

(Treisman et al., 1995)
Allele components
Component
Use(s)
Inserted element
P{PZ}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants persist as third instar larvae for several days, dissection of wandering larvae demonstrates that their CNS is smaller than that of wild type and they lack identifiable imaginal discs. Cell proliferation can occur during the prolonged larval period. Polytene cells of mutant salivary glands and gut appear to grow normally. Clonal analysis in the eye suggests that the mutation causes cell autonomous lethality or failure to proliferate. Ectopic BrdU incorporation suggests the mutant phenotype results from prolonged S phase in the CNS.

      (Treisman et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Mcm2rL074/Mcm2[+] is a suppressor | partially of follicle cell phenotype of E2f21-188, E2f2329

      (Cayirlioglu et al., 2003)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The ectopic genomic replication that is seen in the follicle cells of stage 13 E2f2329/E2f21-188 egg chambers is partially suppressed by Mcm2rL074/+; there is an approximate 65% reduction in the number of follicle cells within an egg chamber that display ectopic genomic replication and there is an apparent reduction in the intensity of ectopic BrdU incorporation.

      (Cayirlioglu et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Complements: grn05930. Complements: sdl02245. Complements: Dlc90F05090b.

      (BDGP Project Members, 1994-1999)

      Excision of the P{PZ} insertion is sufficient to restore viability.

      (Treisman et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      Mcm2rL074
      Mcm2rl74
      (Cayirlioglu et al., 2003)
      l(3)rL074
      (Spradling et al., 1999)
      l(3)rL074rL074
      l(3)rL74
      (Treisman et al., 1995)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)