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General Information
Symbol
Dmel\Mcm2rL074
Species
D. melanogaster
Name
FlyBase ID
FBal0011115
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The 5' end of the transcript is 6bp from the P{PZ} element.

Insertion components
P{PZ}Mcm2rL074
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutants persist as third instar larvae for several days, dissection of wandering larvae demonstrates that their CNS is smaller than that of wild type and they lack identifiable imaginal discs. Cell proliferation can occur during the prolonged larval period. Polytene cells of mutant salivary glands and gut appear to grow normally. Clonal analysis in the eye suggests that the mutation causes cell autonomous lethality or failure to proliferate. Ectopic BrdU incorporation suggests the mutant phenotype results from prolonged S phase in the CNS.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement
Reference

Mcm2rL074/Mcm2[+] is a suppressor | partially of follicle cell phenotype of E2f21-188, E2f2329

Additional Comments
Genetic Interactions
Statement
Reference

The ectopic genomic replication that is seen in the follicle cells of stage 13 E2f2329/E2f21-188 egg chambers is partially suppressed by Mcm2rL074/+; there is an approximate 65% reduction in the number of follicle cells within an egg chamber that display ectopic genomic replication and there is an apparent reduction in the intensity of ectopic BrdU incorporation.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Complements: grn05930. Complements: sdl02245. Complements: Dlc90F05090b.

Excision of the P{PZ} insertion is sufficient to restore viability.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (5)
Reported As
Symbol Synonym
Mcm2rL074
l(3)rL074rL074
Name Synonyms
Secondary FlyBase IDs
    References (6)