FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mam44
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General Information
Symbol
Dmel\mam44
Species
D. melanogaster
Name
FlyBase ID
FBal0012052
Feature type
allele
Associated gene
Dmel\mam
Associated Insertion(s)
P{}mam44
Carried in Construct
Also Known As
mamHD10/6, HD10/6
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
PM hybrid dysgenesis
(Yedvobnick et al., 1988)
Progenitor genotype
Associated Insertion(s)
P{}mam44
Cytology

Polytene chromosomes normal.

(Yedvobnick et al., 1988)
Description

1.6kb P-element insertion near coordinate -50 on the physical map (the 0 coordinate marks the P-element insertion in mam45 - see FBrf0048222), within the first exon.

(Smoller et al., 1990)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      75% of hemisegments show a loss of asymmetry in the division of GMC-1 of the RP2/sib lineage, resulting in two RP2 neurons.

      (Yedvobnick et al., 2004)

      In mutant embryos, both progeny in the RP2sib lineage assume an RP2 indentity in about 65% of hemisegments.

      (Wai et al., 1999)

      Embryonic CNS exhibits moderate disturbances and larval exhibit weak cuticle loss.

      (Schmid et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      mam9

      (Yedvobnick et al., 2004)
      Rescued by

      mam44 is rescued by Scer\GAL4hs.PH/mamN.UAS

      (Yedvobnick et al., 2004)
      Comments

      The loss of asymmetric division in GMC-1 of the RP2/sib lineage seen in mam44 embryos is rescued by expression of mamN.Scer\UAS under the control of Scer\GAL4hs.PH between 6 and 8 hours of development. mam44 and mam9 show interallelic complementation; there is a significant rescue of the loss of asymmetric division in GMC-1 of the RP2/sib lineage, so that most hemisegments show normal specification of the RP2sib neuron in transheterozygotes.

      (Yedvobnick et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      P-element or transposase source: Harwich P strain.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      HD10/6
      (Smoller et al., 1990, Yedvobnick et al., 1988)
      mam44
      mamHD-1D6
      (Wai et al., 1999)
      mamHD10/6
      (Yedvobnick et al., 2004, Schmid et al., 1996)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)