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General Information
Symbol
Dmel\Mhc2
Species
D. melanogaster
Name
FlyBase ID
FBal0012243
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

springer is inserted 5bp 5' to exon 7d. springer is flanked by a 4bp target site duplication. The element is orientated such that they contain a consensus polyadenylation signal, which includes the canonical AAUAAA element, and a GU rich domain within 50 nt 3' of the cleavage site.

Insertion of a 10kb springer element into an intron upstream of exon 7d.

Insertion components
springer{}Mhc2
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Heterozygotes are flightless. Disruptions in the structure of the IFM myofibrils are seen - cracks are visible throughout the myofibril where no thick filaments are present.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments

The flight ability and myofibril phenotypes are fully rescued by one copy of Mhc+t41.9. Duplicated copy of Mhc present on Dp(2;3)osp3 is insufficient to rescue lethality due to the presence of a second site lethal mutation. Mhc+t41.9 can rescue lethality when the second site lethal is recombined off the chromosome.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer

Mogami.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Mhc2
Name Synonyms
Secondary FlyBase IDs
    References (5)